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Registration Number

0225U003075, (0122U000120) , R & D reports

Title

Develop methods for predicting the consequences of cerebral stroke after SARS-Cov2 infection based on the study of blood and cerebrospinal fluid

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Розробити методи прогнозування наслідків церебральних інсультів після перенесеної інфекції SARS-Cov2 на основі вивчення показників крові і ліквору

Head

Piatykop Volodymyr O., д.мед.н.

Registration Date

14-05-2025

Organization

Kharkiv National Medical University

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Оptimization of medical care for patients with hemorrhagic stroke who suffered from SARS-Cov2 infection by identifying biochemical processes that accompany subarachnoid hemorrhage, determining the role of activation of Toll like receptors 4 in the initiation of neuroinflammatory mechanisms and subsequent development of delayed cerebral and cerebral anus , determination of prognostic factors of complications of hemorrhagic stroke on the basis of biochemical parameters of blood and cerebrospinal fluid

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 It was established: activation of the TLR4-dependent mechanism of neuroinflammation in the blood of patients with ischemic strokes against the background of SARS-CoV-2 infection and in the cerebrospinal fluid of patients with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. It has been proven that in patients with SARS-CoV-2 infection, eryptosis is systemically activated in patients, and increased indicators correlate with an increased risk of ischemic complications, and eryptosis in the cerebrospinal fluid can serve as a predictor of ischemic complications in patients with aneurysmal subarachnoid hemorrhage.

Product Description

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Bachynskyi Ruslan O.
Vekshyn Vitalii O.
Horbach Tetiana V.
Kaliuzhka Vladyslav Yu.
Markevych Mykyta A.
Piatykop Volodymyr O.
Posokhov Yevhen O.
Prokopiuk Volodymyr Yu.

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2025-05-14