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Information × Registration Number 0225U003096, (0120U102645) , R & D reports Title Biochemical mechanisms of induction of intestinal inflammation and means of its correction popup.stage_title Біохімічні механізми індукції запалення кишківника та засоби його корекції Head Nakonechna Oksana A., Доктор медичних наук Registration Date 20-05-2025 Organization Kharkiv National Medical University popup.description1 study of biochemical mechanisms of induction of intestinal inflammation, as well as the study of the possibility of correction of experimental enterocolitis nanoparticles of gadolinium orthovanadate with impurities of europium and cerium oxide popup.description2  It was found that rat blood leukocytes were the most sensitive to the toxic effects of carrageenan, which determines the relevance of their use as a model for assessing the state of the intestinal mucosa in inflammatory processes. It was also found that the analysis of leukocyte viability demonstrated that the effect of high concentrations of carrageenans in doses of 5 mg / ml and more directly contributes to the death of leukocytes. It was found that under the conditions of oral administration of sodium dextran sulfate in rats, chronic ulcerative colitis occurs. Under the conditions of immunohistochemistry, Ki67 was highly expressed in epithelial cells of the colon both in intact tissues and when modeling the inflammatory process in the intestine caused by sodium dextran sulfate with a significant increase in expression more than twice in the inflammation group. Product Description popup.authors Babenko Olha V. Bachynskyi Ruslan O. Bondareva Alla V. Briukhanova Tetiana O. Vasylieva Iryna M. Denysenko Svitlana A. Nakonechna Oksana A. Stetsenko Svitlana O. Yarmysh Natalia V. popup.nrat_date 2025-05-20 Close