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Information × Registration Number 0225U003251, (0124U001483) , R & D reports Title Cellular and molecular mechanisms of hypoxia influence in pathological processes associated with combat trauma and its consequences. popup.stage_title Дослідження сигнальних шляхів дії гіпоксії, асоційованих з цитопротекцією та тканинною репарацією. Head Portnichenko Alla H., д.мед.н. Registration Date 06-06-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 To establish the role of hypoxia in pathological processes associated with combat trauma and its consequences (blood loss, tissue damage and repair, inflammation, neurological and metabolic disorders), at the cellular and molecular level, and to develop correction methods. popup.description2  In studies on rats with experimental soft tissue wounds of the limb, the activating role of stress-reactive kinases and hypoxia of the limb in the repair processes and the development of oxidative stress was established. In cultured human cells and tissues of mice, the dose-dependent multidirectional effects of the growth factor IGF-1 and the influence of moderate hypoxia regimes on the activation of cell cycle kinases and cell proliferation processes were characterized. Product Description popup.authors Bakunovskyi Oleksandr M. Vasylenko Maryna I. Vashchenko Nataliia M. Harmatina Olha Yu. Honchar Olha О. Kachalova Olena A. Klymenko Oksana O Kozlovska Mariia H. Mankovska Iryna M. Moiseenko Yevhen V. Portnychenko Alla H. Rozova Kateryna V. popup.nrat_date 2025-06-06 Close