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Information × Registration Number 0225U003271, (0122U001817) , R & D reports Title Development of new compounds for diagnostic and therapeutic applications in nuclear medicine and treatment of malignant tumors popup.stage_title Пошук закономірностей в зміні властивостей одержаних сполук в залежності від будови хелатуючого агента та природи металу. Head Lampeka Rostyslav D., Доктор хімічних наук Registration Date 11-06-2025 Organization Taras Shevchenko National University of Kyiv popup.description1 Development of rational synthetic approaches for obtaining new complexes of transition and rare earth metals of different topology, as well as establishing fundamental laws of the relationship between molecular and crystalline structure of coordination compounds and their bioactivity, and magnetic and optical properties for further development on this basis. creation of a new generation of biomedical compounds and functional materials. popup.description2 The relevance of the work lies in the need to develop new ligand systems and coordination compounds to solve current problems in biomedicine, in particular, the creation of new antitumor agents, contrast agents for magnetic resonance imaging (MRI), as well as functional materials with specific magnetic and optical properties. The aim of the work is to develop rational approaches to the synthesis of new mono- and polynuclear coordination compounds of transition metals of various topologies, to study their structure and functional properties, and to establish fundamental regularities between molecular structure and functional characteristics. The main tasks are: (a) development of synthetic approaches to obtaining complexes using functionalized triazole derivatives; (b) study of the relationships between the structural parameters of coordination compounds and their bioactivity, magnetic and optical properties; (c) creation of complexes with specified topologies of the coordination sphere, which contribute to achieving the target functional characteristics. The main hypothesis of the work: rational design of ligand systems based on triazole derivatives will ensure the formation of coordination compounds with specified properties necessary for their application in biomedicine (antitumor drugs, radiopharmaceuticals) and functional materials (magnetic biomarkers, catalysts). This project opens up prospects for the creation of a new generation of effective and safe compounds capable of solving important problems in modern medicine and nanotechnology.  Product Description popup.authors Doroschuk Roman O. Kazimirov Volodymyr P. Pavlishchuk Anna V. Plutenko Maksym O. Raspertova Іlona V. Khomenko Dmytro M. popup.nrat_date 2025-06-11 Close