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Information × Registration Number 0225U003390, (0124U003939) , R & D reports Title The derivatives of 1,2,4-triazole as promising ligands in the process of creating new domestic drugs popup.stage_title Похідні 1,2,4-триазолу як перспективні ліганди в процесі створення нових вітчизняних лікарських засобів Head Shcherbyna Roman O., Доктор фармацевтичних наук Registration Date 24-06-2025 Organization Shcherbyna Roman O. popup.description1 The main goal of this work is the purposeful creation of new low-toxic and highly active biologically active compounds based on 4-R-5-R1-3-thio-1,2,4-triazole derivatives as potential drugs with antimicrobial and antifungal, analgesic, antipyretic, diuretic, actoprotective, antioxidant, hepatoprotective, growth-stimulating activities with the following prospect of introduction into pharmaceutical practice and medicine. popup.description2 Object of study: An original 1,2,4-triazole derivative molecule with hepatoprotective and antioxidant activity, as well as newly synthesized 1,2,4-triazole derivatives. Aim of study: To complete the preclinical dossier of the original molecule by developing a tablet form for clinical trials and to search for new drug candidates among 1,2,4-triazole derivatives through synthesis, in vitro, and in silico studies. Methods: Modern organic synthesis methods were used. Structural analysis involved spectral methods (NMR, IR spectroscopy, mass spectrometry), elemental analysis, high-performance liquid chromatography, and thin-layer chromatography. Biological activity was assessed via validated in vitro tests (cytotoxicity, antioxidant activity, anti-inflammatory properties). In silico methods included molecular docking, QSAR analysis, and ADMET prediction. Preclinical data were systematized and analyzed. Results: Preclinical data on the original molecule were summarized, confirming its therapeutic potential and safety. Proposals for a stable, bioavailable tablet form were developed, completing the preclinical dossier. New 1,2,4-triazole derivatives were synthesized, and their in vitro and in silico studies identified promising drug candidates with potent activity. Practical significance: The results pave the way for a new Ukrainian drug ready for clinical trials. Established synthesis methods and structure-activity relationships provide a foundation for developing original drugs, enhancing Ukraine’s pharmaceutical independence. Keywords: 1,2,4-triazole derivatives, hepatoprotective activity, antioxidant effect, preclinical studies, tablet form, in silico studies, in vitro studies, drug candidate, pharmaceutical development. Product Description popup.authors Shcherbyna Roman O. popup.nrat_date 2025-06-24 Close