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Information × Registration Number 0225U003639, (0118U004257) , R & D reports Title Search for biologically active substances among azaheterocycles and the development of original and combined medicines popup.stage_title Пошук біологічно активних речовин в ряду азагетероциклів та розробка оригінальних і комбінованих лікарських препаратів Head Kucherenko Liudmyla Ivanivna, Доктор фармацевтичних наук Registration Date 25-07-2025 Organization Zaporizhzhya State Medical University popup.description1 popup.description2 The research work of the Department of Pharmaceutical Chemistry on the topic: "Search for biologically active substances in a series of azaheterocycles and development of original and combined medicinal products" is devoted to the search for new biologically active compounds in a series of azaheterocycles and the creation of new original medicinal products, as well as the creation of new fixed combined medicinal products on the basis of 1,2,4-triazole derivatives, development of the optimal composition and technology of obtaining new medicinal products, as well as methods of their standardization. Modern research methods are used in the work, namely organic synthesis, chemical, physicochemical methods of analysis (NMR, mass, UV, IR, spectroscopy, potentiometry, chromatography, etc.), biological research, computer modeling of processes. Methods of synthesis of starting 1,5-binucleophiles, namely [2-(3-(R-)-1H-[1,2,4]-triazol-5-yl)phenyl] amines have been developed; methods of synthesis of starting 1,5-binucleophiles, 2-cycloalkyl-(hetaryl)-[1,2,4]triazolo[1,5-c] quinazolines were developed; studies on the influence of the nature of 1,2-dielectrophilic reagents on the process of cyclocondensation with substituted 4-hydrazinoquinazolines and quantum chemical calculations of complexes formed by L-apginine, 3-methyl-1,2,4-triazolyl-5-thioacetate (MTTA) and morpholine; carbamazepine and thiotriazoline; L-tryptophan with thiotriazoline were conducted; the selection of auxiliary substances was carried out in order to obtain tablets based on L-apginine with thiotriazoline, carbamazepine with thiotriazoline and L-tryptophan with thiotriazoline by the method of wet granulation, standardization methods were developed, the "Dissolution" test of "Carbatril" tablets was determined, the method of determining thiotriazoline was validated and carbamazepine and methods for determining accompanying impurities in thiotriazoline and carbamazepine tablets by HPLC; optimal conditions for   Product Description popup.authors Avramenko Mykola O. Akopian Rima R. Borsuk Serhii O. Derevyanko Natalia V Kryvoshei Oksana V. Nimenko Hanna R. Portna Olena O. Skoryna Dmytro Yu. Khromylova Olha V. Cherkovska Liudymla H. Shabelnyk Kostiantyn P. popup.nrat_date 2025-07-25 Close