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Information × Registration Number 0225U003663, (0121U111135) , R & D reports Title Bacterial nanovesicles as functional carriers of bioactive agents: interactions with eukaryotic cells popup.stage_title Дослідження шляхів запрограмованої загибелі клітин ссавців під дією асоційованих іх протеазами зовнішньо-мембранних везикул грамнегативних бактерій Komagataeibacter obodiens та Pseudomonas aeruginosa: у макрофагах та злоякісних in vitro клітин. Head Kozyrovska Nataliia О., к.б.н. Registration Date 29-07-2025 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 To study the interaction of bacterial enzyme systems localized on OMV with eukaryotic cells and the possibility of practical use of safe vesicles in order to deliver their own enzyme systems in order to destroy biopolymers in mammalian cells being in a pathological state, such as inflammatory proteins - by using proteasese and extrachromosomal nucleic acids - using bacterial nucleases. popup.description2  Extracellular membrane vesicles of the bacterium Komagataeibacter oboediens are capable of delivering molecular cargo to eukaryotic cells, in particular, therapeutic enzymes (proteases, nucleases) integrated into the membrane of the vesicles, and are promising in wound healing, prevention of upper respiratory tract infections, and drug delivery. Product Description popup.authors Zaiets Iryna Ye. Zubova Hanna V. Korovina Valeriia O. Kukharenko Olha Ye. Melnyk Hanna B. Podolich Olha V. Shcherbyna Mariia V. popup.nrat_date 2025-07-29 Close