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Information × Registration Number 0225U003664, (0118U007139) , R & D reports Title Clinico-pathogenetic and morphological aspects of cardiovascular and renal pathology forming and its stratification in patients with comorbid states, clinical course prognosis and possibilities of pharmacotherapeutic correction popup.stage_title Клініко - патогенетичні та морфологічні аспекти формування та стратифікації кардіоваскулярної і ренальної патології у осіб з коморбідними станами, прогнозування клінічного перебігу та можливості фармакотерапевтичної корекції Head Kraidashenko Oleh V, Доктор медичних наук Registration Date 30-07-2025 Organization Zaporizhzhya State Medical University popup.description1 popup.description2  The object of the study is ischemic heart disease, hypertension, chronic heart failure, chronic kidney disease in people of different age groups. The purpose of the study: based on the analysis of the weighted diagnostic and prognostic significance of clinical and anamnestic, phenotypic, cardiohemodynamic, neurohumoral and metabolic factors, to propose the most optimal method of predicting the adverse course of chronic heart failure in patients with ischemic heart disease with additional cardiovascular risk factors and to improve methods of pharmacological intervention. Research methods: clinical, anthropometric, mathematical, laboratory, instrumental, biochemical, immunoenzymatic, statistical. Based on the study of additional metabolic cardiovascular risk factors in the mobilization of progenitor cells as components of the endogenous reparative system of the heart and vessels, an individualized assessment of the risk of adverse clinical events of various genesis and prediction of treatment effectiveness in patients with chronic heart failure developed as a result of ischemic heart disease was carried out. The treatment strategy for patients with chronic heart failure was improved, taking into account the contribution of angiotensin-2 receptor antagonists to reparative processes and their effect on the mobilization, proliferation and clearance of endothelial progenitor cells with potentially high angiopoietic activity. Product Description popup.authors Dolinna Mariia O. Krasko Mykola P. Kremzer Oleksandr O. Svyntozelskyi Oleksandr O. popup.nrat_date 2025-07-30 Close