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Registration Number

0225U003949, (0121U114060) , R & D reports

Title

633. Condition and correction of autonomic dysfunctions in postcoid syndrome

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Обробка отриманих результатів, розробка алгоритмів і методик діагностики та адекватних терапевтичних заходів щодо пацієнтів з постковідним синдромом

Head

Son Anatolii S., д.мед.н.

Registration Date

18-09-2025

Organization

Odessa National Medical University

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Clinically and pathogenetically substantiate and develop new approaches to the diagnosis and correction of autonomic dysfunction in patients with postcoid syndrome.

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 The study aimed to investigate the role of genetic polymorphisms in the development of cerebral vasospasm (CV) and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). A systematic review and meta-analysis of ApoE, eNOS, and Hp gene polymorphisms were conducted. The Hp2-2 allele was associated with increased risk of CV and DCI, while ApoE4 and eNOS polymorphisms had no significant impact. Biomarkers such as nitric oxide, impaired cerebral autoregulation, and altered cerebral blood flow showed prognostic value. Clinical factors including hemorrhage severity, hemoglobin, hydrocephalus, and stress-induced cardiomyopathy influenced outcomes. CV treatment relies on hemodynamic support and endovascular interventions; pharmacological agents like nimodipine are effective. The study emphasizes the importance of a personalized approach to post-aSAH patients.

Product Description

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Babych Eliza V.
Hnatiuk Iryna M.
Horanskyi Yurii I.
Dobrovolskyi Vasyl V.
Lebid Olena P.
Perkova Hanna V.
Sarazhyna Kateryna S.
Serbin Ihor V.
Solodovnikova Yuliia O.
Stoianov Oleksandr M.
Yarova Kseniia O.

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2025-09-18