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Information × Registration Number 0225U003950, (0120U104835) , R & D reports Title Spacification of the role of epigenetic factors and microbiota in the pathogenesis, clinical course and prevention of migraine popup.stage_title Уточнення ролі епігенетичних чинників та мікробіоти в патогенезі, клінічному перебігу та профілактиці мігрені Head Kopchak Oksana O., Registration Date 18-09-2025 Organization Private Higher Educational Institution "Kyiv Medical University" popup.description1 Improving the diagnosis and improving the effectiveness of pathogenetic-based methods for the prevention of headache attacks in patients with migraine based on the analysis of clinical and neurological characteristics, characteristics of the microbiota, indicators of neuropsychological and laboratory examination. popup.description2  The results of this study have significant scientific novelty within the context of Ukrainian medical science. For the first time in Ukraine, a comprehensive study was conducted on the relationship between migraine, folic acid levels, homocysteine, gut microbiota, and vitamin D. It was found that homocysteine and folic acid levels directly affect headache severity and the quality of life in migraine patients. Additionally, for the first time in Ukraine, the effectiveness of epigenetic and elimination diets in migraine prevention was explored. The introduction of these diets in the treatment of migraine patients showed significant efficacy in reducing the frequency and intensity of headache attacks. The role of the gut-brain axis in migraine pathogenesis was also identified for the first time in Ukraine through an analysis of gut microbiota. Significant differences in microbiota composition were observed in migraine patients compared to healthy individuals. This expands our understanding of the gut-brain connection in the context of migraine and suggests a potential role of microbiota in the pathogenesis of this disorder. The scientific novelty of the developed integrated diagnostic and preventive algorithm for migraine attacks lies in its systematic approach, which combines various aspects of the patient's condition and factors that may influence migraine development. A comprehensive approach to migraine patients based on the results of this study allows for improved diagnostic quality, individualized prevention strategies, and efficient implementation based on each patient's specific needs. Product Description popup.authors Hrytsenko Olena Ye. Kopchak Oksana O. popup.nrat_date 2025-09-18 Close