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Information × Registration Number 0225U004019, (0117U000205) , R & D reports Title Genetic control of metabolism and biochemical properties of the organisms in pathological and stressful conditions with their i mportance for the developmet of diagnostics and therapy. popup.stage_title Молекулярно-генетичний аналіз відібраних за результатами біоінформаційного аналізу, алельних варіантів генів IL1, IL6, IL8, IL10 в групах пацієнтів з сімейними випадками та спорадичними випадками кератоконусу. Встановлення пулу низькомолекулярних метаболітів у хворих на рак простати та нирок. Оцінка дії різних класів інгібіторів гістондеацетілаз на рівень експресії лужної фосфатази і на диференціювання гранулоцитів на первинних культурах хворих на ПМЗ. Комп’ютерна модель та синтез нових інгібіторів. Вивчення реакції на вплив стресових чинників у D.antarctica з використанням культивованого in vitro рослинного матеріалу. Head Telegeev Gennadiy D., Доктор біологічних наук Registration Date 21-10-2025 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 popup.description2 It has been confirmed that polymorphic variants -174G/C of the IL6 gene, -592C/A and -1082G/C of the IL10 gene have a cumulative effect together with the genes identified in the meta-analysis as determinants of pathological processes in the cornea, including the development of keratoconus. New candidate genes have been identified that may be promising for the search for genetic markers of hereditary susceptibility to keratoconus – MPDZNF1B rs1324183 C/A, FNDC3B rs4894535 C/T, ZNF469 rs9938149 C/А.3. A pool of low-molecular-weight metabolites was studied in patients with impaired kidney and liver function, and a significant disturbance in the metabolism of ammonium, arginine, creatinine, and urea ions was found compared to a control group of conditionally healthy people. A design layout for a multi-analytical electrochemical test system for the detection of neurodegenerative diseases and kidney and liver pathologies was developed, using substrate-selective electrodes for the simultaneous determination of ammonium, arginine, creatinine and urea ions. The effect of metformin and vitamin E was studied in K562 leukaemia cell culture as a model of blast crisis in chronic myeloid leukaemia (CML) at the mRNA expression level. It was shown that vitamin E directly stimulates the expression of key factors of myeloid differentiation, in particular, neutrophil granulopoiesis, in a culture of myeloid leukaemia cells K562. It has been established that D. antarctica plants have increased resistance to cadmium ions compared to other vascular plant species. It has been established that UV irradiation with a power of 224 μW/cm2 and a wavelength of 312-405 nm of D. antarctica plants in vitro for 14 days leads to a significant increase in the amount of chlorophyll A and B pigments and carotenoids by 3-3.5 times. Product Description popup.authors Ihor O. Andrieiev Oleksandra V. Horodna Liudmyla A. Livshyts Victor A. Kunakh Korpan Yaroslav I. Liudmyla P. Shvachko Oleksii P. Soldatkin Dziadevych Serhii V. popup.nrat_date 2025-11-03 Close