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Information × Registration Number 0225U004035, (0124U003997) , R & D reports Title Inhibition of Bacterial Settlement and Biofilm Formation through Physical Control of the Environment popup.stage_title Мікроструктурування дослідних поверхонь, дослідження їхніх властивостей та дослідження мікрообрастання цих поверхонь за стаціонарних умов. Head Olena V. Moshynets, Кандидат біологічних наук Registration Date 23-10-2025 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 Microstructuring of experimental surfaces, research of their properties and research of microfouling of these surfaces under stationary conditions. popup.description2  Biofilm formation, or microfouling, is a major bacterial strategy for surface colonization and can occur on any surface where bacteria are present. Bacterial biofilms are difficult to destroy due to their matrix, which consists of strong, adhesive and adaptive polymers, such as eDNA and functional amyloids. The biofilm matrix may become a new target for biofouling elimination. As part of the project, studies were conducted on the anti-biofilm properties of modified stainless steel surfaces, which were obtained by femtosecond laser irradiation, which led to surface modification and the formation of a conical spike or conical groove texture. The topography of the new structures showed the creation of hierarchical nanomicrostructures, which led to greater roughness, and the laser treatment itself changed the microelement composition of the surface. Biofilms of two bacteria, P. aeruginosa PA01 and S. aureus ATCC29423, formed on such a nanotextured metal surface had an altered structure compared to the control. In particular, due to a significant decrease in amyloid production and due to changes in surface adhesion of eDNA, which led to a significant decrease in biofilm biomass. Thus, the relief of the metal surface radically reduces biofilm development solely by changing the architecture of the biofilm. The results obtained are important for the development of antibacterial surfaces for various applications. Product Description popup.authors Yunhin Olha S. popup.nrat_date 2025-10-23 Close