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Information × Registration Number 0225U004202, (0124U001685) , R & D reports Title Molecular and genetic mechanisms of neurodegeneration in mouse brain involving proinflammatory cytokines in the modeling of posttraumatic stress disorder popup.stage_title Вивчення значення некодуючих РНК – днкРНК та мікроРНК - при моделюванні посттравматичного стресового розладу Head Dosenko Viktor Ye., Доктор медичних наук Registration Date 25-11-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 The aim of the study is to establish the pathogenetic significance of non-coding RNAs, hypoxia-inducible factor, senescent cells and neuroinflammation in PTSD and to evaluate the effectiveness of experimental therapy of this disease using intermittent hypoxia-hyperoxia and specific inhibitors of HIF prolyl hydroxylase. popup.description2 Using reverse transcription and real-time polymerase chain reaction, the relative mRNA expression of Adcyap1, Adcyap1r1, Vipr1, Vipr2, and BDNF in the hippocampus and prefrontal cortex of mice was evaluated. Analysis of the results showed no differences in gene expression in the hippocampus. Still, a significant difference was seen for certain genes in the prefrontal cortex of mice with experimental PTSD. Product Description popup.authors Ruslan B. Strutynskyi Viktor Y. Dosenko Stroi Dmytro О. Vasyl S. Nagibin Angela M. Shysh Denys O. Pashevin Lesia V. Tumanovska Mykhaylo R. Hetsuriani Tetiana I. Lahuta popup.nrat_date 2025-11-25 Close