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Information × Registration Number 0225U004206, (0124U001370) , R & D reports Title Mechanisms and ways of correction of regulated cell death of the immune (thymus and lymphatic nodes) and reproductive (ovaries and testes) systems. popup.stage_title Дослідження ефективності застосування препаратів-антагоністів ПАРП за умов активації Т-клітинного ланцюга імунної відповіді. Моделювання окисного стресу in vitro клітин яєчника та розробка експериментальної моделі цукрового діабету, поєднаного з хронічною хворобою нирок. Head Voznesenska Tetyana Yu., Доктор біологічних наук Registration Date 26-11-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 To investigate the influence of various substances on the mechanisms of the development of cell death of the immune and reproductive systems in the simulation of: LPS-induced endotoxemia, premature ovarian failure, oxidative stress in vitro, diabetes and chronic kidney disease and to evaluate the protective effect of these substances. popup.description2  The scientific work of the department is devoted to the study of the degree of DNA damage of immunocompetent cells when poly(ADP-ribose) polymerase inhibitors are used under the conditions of activation of the T-cell chain of the immune response. The assessment of the viability of the cells of the follicular environment of oocytes under the conditions of in vitro oxidative stress modeling is given. A new experimental combined model was obtained, which in the future can be used to establish features and reveal possible pathogenetic links in the development of reproductive dysfunction in males. Product Description popup.authors Nataliia O. Krasutska Роман І. Янчій Hrushka Nataliia H. Blashkiv Taras V. Tetiana Y. Voznesenska Svitlana I. Pavlovych Olena А. Kondratska Oksana M. Kaleinikova Valentyna O. Sribna Pilkevych Nataliia O. Аlina P. Lytvynenko Vladyslava V. Meshko Iryna I. Andriichuk popup.nrat_date 2025-11-26 Close