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Registration Number

0225U004213, (0122U001154) , R & D reports

Title

Physical bases of formation of apatite-biopolymer-carbon 3D nanometric scaffolds for biomedical purpose with prolonged delivery of antimicrobials to the implantation area

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Фармакокінетика та мікробіологічні властивості апатит-біополімерних нанометричних 3D матриць. Розробити методику поверхневої мінералізації полімерних (СS, Alg) нанофібрил. Розробити апатит-біополімерні 3D матриці для проліферації мезенхімальних стовбурових клітин

Head

Sukhodub Leonid F., д.ф.-м.н.

Registration Date

26-11-2025

Organization

Sumy State University

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Establishing the physical basis for the formation of 3D nanometric matrices based on calcium deficiency hydroxyapatite (cdHA), as well as natural polysaccharides of chitosan (CS), alginate (Alg), carbon nanoparticles, bioactive substances, mesenchymal stem cells and laying the foundation for creating biomaterials with specified functional characteristics both the consequences of socially significant human diseases (military, industrial and domestic injuries) and the improvement of quality of life through the introduction of comprehensive therapies

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This work presents comprehensive research on the development and evaluation of bioactive composite materials based on natural polymers for regenerative medicine. For the first time, the dependence of ceftriaxone release kinetics on the impregnation method and the formation technique of alginate–gelatin 3D matrices modified with hydroxyapatite (HA) nanoparticles and multi-walled carbon nanotubes (MWCNTs+Fe) was established. It was demonstrated that the fabrication method (mould-shaping or 3D printing) influences the structural parameters of the composites and, consequently, the drug release profile, enabling the adjustment of the material to the type of wound exudate. Biocompatible porous fibrillar structures composed of alginate, gelatin, and calcium phosphates were synthesized and modified with fetal bovine serum (FBS) and cord blood serum (CBS), which enhanced mesenchymal stem cell viability. The developed film dressings and 3D composites demonstrated optimal swelling, porosity, and fluid retention characteristics meeting the requirements for infected wound treatment materials. In vivo experiments with Alg/CS/cdHA matrices impregnated with platelet-rich plasma (PRP) confirmed their biocompatibility, osteoconductivity, and biodegradability. These materials ensured complete regeneration of parietal bone defects in animals within 165 days. A comparative analysis of osteogenic composites Alg_HA and CS_DCPD revealed a higher regenerative potential for alginate-based systems, supported by morphological and CT data, as well as by an examination of vitamin D₃ release kinetics. Additionally, electroactive nerve conduits based on Alg/Gel matrices modified with ZnO, fullerene C₆₀, and polyaniline (PANI) nanoparticles were developed. These composites combine high electrical conductivity, antioxidant activity, and biocompatibility, promoting peripheral nerve recovery through the formation of Büngner bands.

Product Description

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Nataliia V. Bozhko
Leonid F. Sukhodub
Oleksii V. Korenkov
Liudmyla B. Sukhodub
Mariia O. Kumeda

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2025-11-26