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Information × Registration Number 0225U004225, (0124U001683) , R & D reports Title Pharmacological regulation of ligand- and mechano-gated ion channels. popup.stage_title Визначити вплив фоточутливого нікотину на функціональні відповіді різних типів клітин, що експресують ацетилхолінові рецептори нікотинового типу (нАХР). Head Shuba Yaroslav М., Доктор біологічних наук Registration Date 26-11-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 The aim of the research is to establish the role of mechanosensitive membrane ion channels from the TRP and PIEZO family in the regulation of vascular and bladder smooth muscle tone (detrusor) and the behavior of stromal cells (connective tissue cells that create the infrastructure of any organ), as well as obtaining experimental facts for the development of methods of photoinduced release of pharmacological substances with channel-specific action using the example of photosensitive nicotine. popup.description2 Comparative studies of the effects of regular nicotine and its light-activated form - RuBi-nicotine, as a model compound for developing photo-pharmacology principles - have demonstrated a similarity in their long-term effects on cancer cell proliferation, but a difference in their ability to activate membrane current through nicotinic acetylcholine receptors or induce contraction of smooth muscle preparations. Product Description popup.authors Yaroslav М. Shuba Ihor B. Filipov Hanna V. Sotkis Semen I. Yeliashov Danylo I. Kravchuk popup.nrat_date 2025-11-26 Close