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Registration Number

0225U004277, (0123U102850) , R & D reports

Title

Research And Development Of Ion-Plasma Technologies for Synthesis of Complex Composite Multifunctional Coatings For Medical Implants And Biosafety

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Біомедичні дослідження синтезованих покриттів на експери¬ментальних зразках, медичних імплантатах та виробах широкого використання, визначення оптимальної технології синтезу покриттів, яка забезпечує найкращі біологічні властивості, розробка рекомендації щодо застосування нових типів композитних покриттів

Head

Lisovskyi Valerii O., Доктор фізико-математичних наук

Registration Date

27-11-2025

Organization

V.N. Karazin Kharkiv National University

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Research and development of technologies of ion-plasma synthesis of multifunctional (protective, bioinert, antibacterial) multilayer coatings based on oxides and nitrides of transition metals on the surface of metal and polymeric medical implants, research of physico-mechanical and electrochemical properties of the coatings, and justification of the coatings application by in vivo studies of the body's biological response to the coated implant.

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Comprehensive experimental research and development of technologies for ion-plasma synthesis of multifunctional (protective, bioinert, antibacterial) multilayer coatings based on oxides and nitrides of transition metals on the surface of metal and polymer medical implants were carried out, the physicomechanical and electrochemical properties of the coatings were investigated, and the biochemical and morphological justification of the use of tantalum-based coatings in surgical practice was carried out using in vivo studies of the biological response of the body to the parameters of coatings of metal and plastic implants. The basis for these technologies is a new combined magnetron-ion-beam system developed by the project's authors, which enables the formation of stationary and charge-compensated flows of low-energy ions (10-300 eV) with a controlled mass composition of reactive gases. The biocompatibility of the synthesized coatings was evaluated using laboratory animals by a combination of such modern methods as studying the degree of intoxication and the content of acute phase proteins (C-reactive protein, haptoglobin, ceruloplasmin) in the blood of experimental animals after implantation of different types of samples with coatings, assessing the viability of leukocytes, types of their cell death and the state of the phospholipid bilayer of leukocyte membranes using a set of fluorescent probes after implantation of samples with different coatings. As a result, it was biochemically and morphologically substantiated that the use of surgical meshes with a coating based on tantalum and tantalum oxide significantly improves the biocompatibility of the implant and does not provoke the development of a long-term inflammatory process, which can lead to the occurrence of adhesive and purulent-septic processes at the implantation site. Microbiological testing of antibacterial coatings was carried out using cultures of Escherichia coli and Staphylococcus aureus. The results o

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Azarienkov Mykola O.
Zykov Oleksandr V.
Yakovin Stanislav D.
Dudin Stanislav V.
Mazilin Bohdan O.
Nina Yefymenko

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2025-11-27