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Information × Registration Number 0225U004332, (0124U001542) , R & D reports Title Functional features of neurons of the central and autonomic nervous systems in models of systemic pathological conditions. popup.stage_title Дослідження механізмів впливу короткотривалої гіпоксії на високопорогові кальцієві канали в культивованих гангліозних клітинах сітківки та ефективності глутаматергічної нейропередачі в ноцицептивних синапсах нейронів спінальних гангліїв на нейронах дорзального рогу спинного мозку в моделі штучної гіперглікемії та гіпоінсулінемії. Head Veselovskyi Mykola S., Доктор біологічних наук Registration Date 01-12-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 Elucidation of the main mechanisms of dysregulation of electrical activity and synaptic dysfunction of neurons of the peripheral and central nervous system in hyperglycemia, hypoinsulinemia, hypoxia and insulin resistance and determination of methods of their correction. popup.description2 Cytosolic calcium plays a key role in the regulation of retinal homeostasis, with voltage-gated calcium channels being the main pathway for calcium entry into the cell. Dysfunction of high-threshold calcium channels is associated with several neurological problems. We focused on identifying and assessing the initial effects of acute hypoxia on somatic calcium VPCCs and their recovery during reoxygenation in retinal ganglion cell culture. We investigated the efficacy of glutamatergic neurotransmission at nociceptive synapses of spinal ganglion neurons on dorsal horn neurons of the spinal cord in an in vitro model of artificial hypoinsulinemia. Using the patch-clamp method in the "whole cell" configuration and the method of local electrical stimulation of the presynaptic axon in a co-culture of neurons of the spinal ganglia and dorsal horn of the rat spinal cord, we analyzed the parameters of short-term plasticity (plasticity upon paired stimulation) in glutamatergic nociceptive synapses. Product Description popup.authors Yaroslav М. Gotsulyak Mariia S. Shypshyna Kyrylo І. Kuznetsov Hanna V. Dumanska Svitlana A. Fedulova Mykola S. Veselovskyi Purnyn Olena E. Oleh V. Rykhalskyi Vitalii Y. Maslov Serhii V. Voitenko Ihor M. Remizov popup.nrat_date 2025-12-01 Close