Search academic texts

Information × Registration Number 0225U004432, (0124U003843) , R & D reports Title Cross-talk between GABAARs and ASICs as a novel target for stress-induced insomnia. popup.stage_title Взаємодія між ГАМКА рецепторами та ASIC каналами у якості новітньої молекулярної мішені для терапії стрес-індукован ої інсомнії. Пошук нових модуляторів та первинна оптимізація. Head Krishtal Oleg O., Доктор біологічних наук Registration Date 05-12-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 The project aims to develop the latest chemical probes using chemical genetics methods to modulate the activity of GABA receptors and ASIC channels and the subsequent application of the obtained data for the correction of sleep disorders. In addition, the project will provide fundamental knowledge about the role of ASIC channels in the regulation of circadian activity. popup.description2 Within the interim stage of the project, a set of studies was carried out aimed at identifying and preliminarily validating new positive allosteric modulators of GABA ? Areceptors. The work included modeling the structural characteristics of the receptor, computer-based screening of potential compounds, their chemical synthesis, and initial in vitro functional testing. The research was conducted in accordance with the planned workflow and involved the use of modern tools of molecular modeling and electrophysiology. Product Description popup.authors Olena V. Yehorova Vyacheslav B. Kulyk Oleg O. Krishtal Andrii О. Cherninskyi popup.nrat_date 2025-12-05 Close