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Total number
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Number of local repositories
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0225U004432,
(0124U003843)
,
Cross-talk between GABAARs and ASICs as a novel target for stress-induced insomnia.
Взаємодія між ГАМКА рецепторами та ASIC каналами у якості новітньої молекулярної мішені для терапії стрес-індукован ої інсомнії. Пошук нових модуляторів та первинна оптимізація.
Krishtal Oleg O., Доктор біологічних наук
05-12-2025
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
The project aims to develop the latest chemical probes using chemical genetics methods to modulate the activity of GABA receptors and ASIC channels and the subsequent application of the obtained data for the correction of sleep disorders. In addition, the project will provide fundamental knowledge about the role of ASIC channels in the regulation of circadian activity.
Within the interim stage of the project, a set of studies was carried out aimed at identifying and preliminarily validating new positive allosteric modulators of GABA ? Areceptors. The work included modeling the structural characteristics of the receptor, computer-based screening of potential compounds, their chemical synthesis, and initial in vitro functional testing. The research was conducted in accordance with the planned workflow and involved the use of modern tools of molecular modeling and electrophysiology.
Olena V. Yehorova
Vyacheslav B. Kulyk
Oleg O. Krishtal
Andrii О. Cherninskyi
2025-12-05
Updated: 2025-12-05
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