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0225U004555,
(0124U003464)
,
Molecular mechanisms of the therapeutic effect of the transplantation of placental mesenchymal stromal cells in the treatment of mine-explosive injuries of the lower limbs in humans
Оцінка ефективності та молекулярно-біологічних механізмів, що лежать в сонові терапевтичного впливу ПМСК на мінно-вибухові рани
Shablii Volodymyr A., Кандидат біологічних наук
11-12-2025
Institute of Molecular Biology and Genetics of NAS of Ukraine
The goal of the project is to clarify the molecular mechanisms of the therapeutic effect of transplantation of human placental mesenchymal stromal cells (PMSCs) on the healing of landmine-explosive limb wounds in complex surgical treatment.
Studies were conducted to evaluate the effectiveness of local application of cryopreserved human umbilical cord mesenchymal stromal cells (hUC-MSC) with a comprehensive surgical approach in the treatment of mine-explosive wounds of the lower extremities. 15 patients participated in the study. In the group of patients receiving MSC injections, the safety of therapy and stimulation of granulation, reduction of microbial load without a negative impact on clinical healing rates were demonstrated. In both groups, the relative wound area gradually decreased during the observation period, while the wound healing rate in the control group and the MSC group did not differ. Transcriptomic analysis indicated early suppression of the immune response and activation of blood circulation and muscle contraction processes, while on day 7, modulation of chemokine pathways and regulation of immune mechanisms were observed. In vitro hUC-MSCs reduced the proliferation and pro-inflammatory activity of immune cells, promoting the formation of an anti-inflammatory phenotype of macrophages and changing T-lymphocyte subpopulations. The obtained data confirm the feasibility of using hUC-MSCs as a safe and promising adjuvant method in the complex treatment of complex blast defects of the lower extremities, which requires further clinical studies to evaluate and study the long-term effects, systemic and local effects of intrawound hUC-MSC injections on the immune system and reconstructive interventions.
Руслан В. Салютін
Ustymenko Alina M.
Skrypkina Inessa Ya.
Bukreieva Tetiana V.
Symulyk Yevhen V.
2025-12-11
Updated: 2025-12-15
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