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Information × Registration Number 0225U004569, (0120U104649) , R & D reports Title Design, synthesis, molecular structure and physicochemical characteristics of highly selective calixarene receptors of molecules and ions for the creation of functional substances and materials for biomedical and technical purposes popup.stage_title Дизайн, синтез, молекулярна будова та фізико-хімічні характеристики високоселективних каліксаренових рецепторів молекул та іонів для створення функціональних речовин і матеріалів біомедичного та технічного призначення Head Kalchenko Vitalii I., Доктор хімічних наук Registration Date 11-12-2025 Organization Institute of Organic Chemistry NAS of Ukraine popup.description1 The aim of the project is to develop new types of calixarenes capable of selective recognition, binding and separation of biologically active and environmentally hazardous molecules and ions, and to create on the basis of the obtained calixarenes the functional substances and materials for medical, biological and technical purposes. popup.description2 In order to obtain new biologically active compounds, synthesis methods were developed and calixarenes and thiacalixarenes modified with fragments of phosphoric, methylenebisphosphonic, α-ketophosphonic, and hydroxymethylenebisphosphonic acids were synthesized, and the structure, complexation ability, and biological activity of the obtained compounds were investigated. A series of optically pure inherently chiral calixarenoacetic acid derivatives with different alkyl groups on the lower rim were synthesized, their structure and absolute stereochemical configuration were determined, and the enantiodiscriminatory properties of the synthesized monoalkyloxy- and dialkyloxycalix[4]arenoacetic acids were investigated. Calixarene-α-ketophosphonic acids, calixarene-methylenebisphosphonic and thiacalixarene phosphoric acids have been shown to be effective inhibitors of protein tyrosine phosphatases (IC50=1.9 μM). It has been demonstrated that amphiphilic calixarene-hydroxymethylene-bisphosphonic acids form micelles in aqueous solutions. Micelles form complexes with polylysine and HIV-1 nucleocapsid proteins labeled with fluorescent groups. The formed complexes pass through biological membranes into the cell, which opens up prospects for creating targeted delivery systems for peptide drugs. Product Description popup.authors Roman V. Rodik Hanna S. Sviatnenko Lidiia S. Dovhopiata Serhii O. Cherenok Hanna O. Lisova Anna I. Selikhova Vitaly I. Kalchenko Illia S. Forys Oleksandr A. Yesypenko Andriy B. Drapailo Lyudmila I. Atamas Sergiy G. Vyshnevskiy Larysa O. Bondarchuk Yurii S. Boiko popup.nrat_date 2025-12-11 Close