Search academic texts

Information × Registration Number 0225U004633, (0123U102860) , R & D reports Title Study of the circulation of zoonotic influenza A viruses in the natural reservoir, assessment of their epidemic risks and danger to human health in Ukraine popup.stage_title Секвенування зоонотичних вірусів грипу, їх філогенетичний аналіз Head Stehnii Borys , Доктор ветеринарних наук Registration Date 15-12-2025 Organization National Scientific Center Institute of Experimental and Clinical Medicine popup.description1 To study the peculiarities of circulation, new sources of zoonotic influenza A viruses (animal influenza virus, bird influenza virus) with pandemic potential (subtypes H1, H2, H3, H5, H7, H9, etc.), among domestic, wild animals, birds in Ukraine and assess the danger of these viruses to human health. popup.description2 6. Large-scale monitoring of influenza virus circulation among wild Passeriformes in Ukraine was conducted (1,429 wild birds of 60 species belonging to 19 families were examined). Serological testing revealed antibodies to influenza A virus in 1.08% of passerines, while PCR results showed an unexpectedly high infection rate of 1.42–9.09%, depending on the species. Circulation of influenza A virus subtypes important for both poultry and public health subtypes (H1N1, H1N2, H3N8, and H7N1) was detected in wild passerines in Ukraine. Epizootiological monitoring of influenza A circulation among domestic and wild mammals in Ukraine demonstrated active circulation of this pathogen. High seropositivity rates were consistently observed in unvaccinated swine (6.2–59.5%) and horses (0–60.9%) across 11 regions of Ukraine. In domestic swine, circulation of influenza subtypes H1N1 (including pandemic H1N1pdm), H1N2, and H3N8 was confirmed by PCR and virus isolation. Of particular importance is the detection of evidence of influenza A circulation (including highly pathogenic avian influenza H5N1) in domestic animals (cats -3.8-30.2%; dogs -5.5-24.4%), wild carnivores (foxes, 3.7-15.8%), wild boars (30.6%) and other mammals. These findings indicate that the virus is overcoming the interspecies barrier, which may facilitate the emergence of new viral variants and pose a risk for future pandemics. Expanded serological studies in mammals allowed us, for the first time in Ukraine, to detect circulation of the novel influenza D virus. Genetic analysis and 3D modeling to date have not revealed critical mutations in receptor-binding sites of influenza viruses circulating in natural hosts in Ukraine. Overall, the results underscore the importance of continuing surveillance of influenza viruses in their natural reservoir. Product Description popup.authors Alla P. Mironenko Oleksandr M. Rula Polina Yurko Nataliia M. Muzyka Semen V. Tkachenko Anton B. Stehnii Larissa Radchenko popup.nrat_date 2025-12-15 Close