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Information × Registration Number 0225U004687, (0125U001713) , R & D reports Title Development of personalized criteria for assessing high cardiovascular risk based on markers of cellular aging popup.stage_title Оцінка високого кардіо-васкулярного ризику за маркерами клітинного старіння у хворих, які перенесли невідкладні кардіологічні стани з супутнім документованим COVID-19 Head Parkhomenko Oleksandr M., Доктор медичних наук Registration Date 17-12-2025 Organization State Institution National Scientific Center the M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine popup.description1 To establish new comprehensive pathogenetically based approaches to assessing the risk of cardiovascular complications in patients after cardiac emergencies, taking into account markers of cellular aging to increase the effectiveness of personalized therapy. popup.description2 Understanding the molecular and cellular basis of aging in the context of cardiovascular diseases is of paramount importance for the development of effective preventive and therapeutic strategies. The idea of ​​the project is to establish new criteria for cardiovascular risk based on markers of cellular aging. Determining the characteristics of senescent cells in the blood of patients with cardiovascular diseases will allow obtaining new knowledge about the mechanisms of aging and the course of age-associated pathology, especially against the background of COVID-19 and under the influence of stress factors of the COVID-19 pandemic and martial law. The goal of the project is to establish new comprehensive pathogenetically based approaches to assessing the risk of cardiovascular complications in patients after suffering cardiac emergencies, taking into account markers of cellular aging to increase the effectiveness of personalized therapy. In patients of high cardiovascular risk group who have undergone urgent cardiac conditions before the COVID-19 pandemic, with concomitant diagnosed COVID-19 and against the background of stress-associated factors of the pandemic, the manifestations of endothelial dysfunction will be verified using instrumental and laboratory research methods, and markers of cellular aging will be determined using cytological, immunological and molecular genetic methods. As a result, a comprehensive correlation analysis of the identified markers of cellular aging with established markers of endothelial dysfunction will be conducted to assess homeostasis at the level of the cardiovascular system and individual assessment of cardiovascular risk under the influence of negative stress-associated factors of the pandemic and wartime. Product Description popup.authors Ustymenko Alina M. Oleh M. Tsupikov Oleksandr A. Skarzhevskyi Kyryk Vitalii M. Khomiakov Dmytro V. popup.nrat_date 2025-12-17 Close