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0225U004705,
(0125U000969)
,
Development and optimisation of genotyping techniques for the High mobility group AT-hook 1 (HMGA1) gene in pigs
Розроблення і оптимізація техніки генотипування за геном High mobility group AT-hook 1 (HMGA1) у свиней
Saienko Artem M., Кандидат сільськогосподарських наук
17-12-2025
Institute of pig breeding and agrarian production of The National Academy of Agrarian Scienses
To develop and optimise the technique of genotyping for the High mobility group AT-hook 1 (HMGA1) gene as a molecular genetic marker responsible for lipid regulation and pork quality with the prospect of using it in marker-assisted selection
Improving the efficiency of pig breeding in modern intensive livestock farming is impossible without the use of molecular genetic approaches that provide an accurate assessment of hereditary variability in terms of economically useful traits. SNP markers, which allow the identification of associations between certain genetic variants and phenotypic characteristics of animals, are of particular interest. Among the promising candidate genes, HMGA1 (High Mobility Group AT-hook 1) stands out — a gene located on the 7th chromosome (SSC7) of pigs, in a region containing several QTLs responsible for meat, fattening, and reproductive traits. The HMGA1 gene product is involved in the regulation of transcription, cell growth, proliferation, differentiation, and metabolic processes, which determines its selection value. The results of numerous studies (2009–2024) indicate its association with backfat thickness, growth rate, carcass meatiness, feed conversion ratio, and energy metabolism level. The aim of the study was to develop, bioinformatically substantiate, and experimentally optimize a PCR genotyping method for the HMGA1 gene as a potential molecular genetic marker of pig productivity, as well as to identify the polymorphism of this gene in a sample of Large White pigs. Translated with DeepL.com (free version)
Dmytro S. Dubinin
Lobchenko Oleksandra V.
Volodymyr V. Teniaiev
2025-12-17
Updated: 2025-12-17
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