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0225U004717,
(0125U003007)
,
Sequencing and analysis of complete genomes of bacteriophages isolated in Ukraine as an important step towards realizing their therapeutic potential
Відновлення з колекції/виділення нових бактеріофагів Klebsiella pneumoniae з довкілля з наступним виділенням нуклеїнової кислоти та секвенуванням їхніх геномів
Kharina Alla V., Кандидат біологічних наук
17-12-2025
Taras Shevchenko National University of Kyiv
Conducting a comprehensive characterization using next-generation sequencing (NGS) of new Ukrainian bacteriophage isolates capable of infecting bacteria of public health importance as a basis for advancing phage-based therapeutic strategies to combat antibiotic resistance (ADR).
Antimicrobial resistance (AMR) is a critical issue in Ukraine, largely impacted by the ongoing military conflict, with nosocomial infections, caused by multidrug-resistant (MDR) bacteria being a major concern. Unregulated antibiotic therapy during medical evacuations, combined with overwhelmed healthcare facilities, led to the rapid emergence and a wide spread of MDR strains within the country. Phage therapy, which uses highly specific bacteriophages (phages) to combat bacterial pathogens, is a promising alternative to traditional antibiotics. However, a comprehensive characterization of phages, including whole genome sequencing to prove their safety, is a prerequisite for their practical use. In this project, we will conduct a whole-genome characterization of a collection of bacteriophages active against Ukrainian isolates of the three relevant pathogens of the ESKAPE group: Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. This will be the first such large-scale effort in Ukraine, allowing the selection of the most promising candidate phages and paving the way for new treatments in the fight against the AMR crisis.
Galyna O. Snigur
Tetiana P. Shevchenko
Iryna H. Budzanivska
Oleksii V. Shevchenko
Oleksandra Y. Mormil
2025-12-17
Updated: 2025-12-17
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