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0225U004744,
(0125U001950)
,
Nanostructural modification of application drugs for military medical technologies
Модифікація АЛЗ для загоєння ран за допомогою полімерних носіїв та наночастинок
Doroshenko Iryna Yu., Доктор фізико-математичних наук
18-12-2025
Taras Shevchenko National University of Kyiv
Creation of new-generation modified application drugs, which include wound-healing, anti-inflammatory, antimicrobial and anesthetic ingredients, polymer carriers, excipients with defined dosage and nanostructures, for the treatment of complex wounds after combat trauma and conducting complex physical and pharmacokinetic studies to establish mechanisms of increasing the effectiveness of medicinal products on regeneration processes during wound healing.
The study presents the results of developing and investigating multicomponent semisolid dosage forms - an ointment and a cream with anti-inflammatory, antimicrobial, anesthetic, and wound-healing properties, modified with silver and cerium dioxide nanoparticles. The composition of the base was optimized, and the technological as well as physicochemical compatibility of the components, together with the stability of the preparations during six months of storage, were confirmed. Spectroscopic analyses and molecular modeling revealed the mechanisms of complex formation between ibuprofen, serum albumin, and nanoparticles, explaining the specific features of binding, transport, and the potential bioavailability of the active substances. The obtained results justify the development of a multifunctional agent for wound treatment, including combat-related injuries, and demonstrate the feasibility of using inert polymer matrices for the safe delivery of pharmaceutical compounds.
Lesiuk Andrii I.
Dmytrenko Oksana P.
Kulish Mykola Polikarpovych
Давтян Лена Левонівна
Anna O. Drozdova
2025-12-18
Updated: 2025-12-18
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