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Information × Registration Number 0225U004918, (0125U002523) , R & D reports Title Study of the effect of PM complexes with pollutants on susceptibility to the development of more severe symptoms of Parkinson's disease induced by 6-OHDA or LPS and Alzheimer's disease induced by infusion of 1-40 beta-amyloid peptide in an animal model Analysis of monitoring data of SARS-CoV-2 infection and PM air pollution. popup.stage_title Дослідження впливу комплексів РМ із забруднювачами на сприйнятливість до розвитку більш серйозних симптомів хвороби Паркінсона індукованої 6-OHDA або LPS на тваринній моделі (тест на апоморфін, рівень ТН у нейронах мозку, тест «відкрите поле»). На основі отриманих експериментальних даних виконати математичне моделювання та аналіз кореляції між даними моніторингу інфікування SARS-CoV-2 та забрудненням повітря РМ з використанням різних баз даних моніторингу навколишнього середовища. Дослідження впливу комплексів РМ із забруднювачами на сприйнятливість до розвитку більш серйозних симптомів хвороби Альцгеймера, індукованої інфузією 1-40 бета-амілоїдного пептиду у щурів (когнітивні функції та відкладення бета-амілоїду та тау-протеїну у лікворі (CSF), рівень ТН у нейронах мозку). Head Dziubenko Nataliia V., Кандидат біологічних наук Registration Date 22-12-2025 Organization Taras Shevchenko National University of Kyiv popup.description1 Characterization of the effect of PM complexes with pollutants on susceptibility to the development of more severe symptoms of Parkinson's disease using an animal model. Data from mathematical modeling and analysis. Characterization of the effect of PM complexes with pollutants on susceptibility to the development of more severe symptoms of Alzheimer's disease using an animal model. Based on the experimental data obtained, perform mathematical modeling and analysis of the correlation between SARS-CoV-2 infection monitoring data and PM air pollution using various environmental monitoring databases. popup.description2 PARTICULATE MATTER, ACE2, LEAD, CADMIUM, MAEC-CELLS. The object of the research is ACE 2 receptors, monitoring data on the spread of SARS-CoV-2 infection and air pollution in the Republic of Moldova. Aim of the study – to investigate the cumulative neurotoxic effects of multicomponent PM pollution combined with neuroactive pharmaceutical contaminants, biomaterials, and toxic metals using an original approach to neurotoxicity assessment based on animal models; to identify PM types capable of acting as pollutant carriers; to determine the molecular mechanisms of neurotoxicity; to explore the relationship between PM and susceptibility to SARS-CoV-2; and to propose potential countermeasures. Research methods – mathematical modeling, modeling of Alzheimer’s and Parkinson’s diseases, and statistical analysis. It was shown that modeling of Alzheimer’s disease is accompanied by memory impairment, decreased tyrosine hydroxylase, catalase activity, and SH-groups, as well as increased levels of Aβ, Tau protein, and markers of inflammation and oxidative stress. Poplar wood smoke (PS) may exhibit both neuroprotective and toxic effects, whereas lead (Pb) induces pronounced neurotoxicity. Combined exposure to PS and Pb exerts a cumulative toxic effect, intensifying cognitive impairment and inflammatory responses. In the Parkinson’s disease model, a decrease in tyrosine hydroxylase, increased rotational behavior, and reduced motor activity were observed. Exposure to PS and Pb aggravated these disturbances, particularly under Pb influence. Overall, toxic components of air pollution can exacerbate neurodegenerative processes characteristic of Alzheimer’s and Parkinson’s diseases. Product Description popup.authors Valentyn V. Sobchuk Korbush Mariia Yu. popup.nrat_date 2025-12-22 Close