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Information × Registration Number 0225U005035, (0124U004358) , R & D reports Title Development of the latest titanium implants for osteosynthesis with a surface modified with a magnesium alloy and nanoparticles of silver and copper popup.stage_title Дослідження механічних властивостей структури; нанесення біологічно активних покриттів; адаптація відібраних методів формування біоплівки. Отримання сплавів, вивчення корозійної стікості сплавів та структури, дослідження біоактивності. Head Hornostai Oleksii V., Кандидат технічних наук Registration Date 24-12-2025 Organization E.O. Paton Electric Welding Institute (PWI) popup.description1 The goal of the project is to modify the surface of titanium implants for osteosynthesis with a magnesium-based alloy with the addition of silver and copper nanoparticles to improve bone regeneration, corrosion resistance, biocompatibility, and antibacterial properties of the implants. popup.description2 Within the third stage of the research work, a comprehensive set of experimental studies was conducted to evaluate the mechanical, corrosion, and biofunctional characteristics of magnesium-based coatings. Coating samples of chemically pure magnesium and a quaternary Mg–Zn–Ca–Ga alloy were fabricated by microplasma spraying onto VT1-0 grade titanium substrates. It was established that Mg–Ti coatings exhibit high tensile adhesion strength, reaching 36 MPa, whereas Mg alloy–Ti coatings demonstrate lower adhesion values of approximately 11 MPa, which is attributed to the structural and phase-specific features of the alloyed material. The shear adhesion strength of both Mg–Ti and Mg alloy–Ti coatings is lower, amounting to 21 MPa and 24 MPa, respectively, which is expected due to the nature of shear loading. Simulation of realistic physiological operating conditions was performed using an experimental “bone–implant” system with osteosynthesis screws inserted into human bone tissue under controlled torque, followed by mechanical loading under static and cyclic regimes. The obtained results confirmed the preservation of coating integrity after mechanical loading, indicating the potential suitability of the developed magnesium-based coatings for clinical application. Immersion corrosion tests demonstrated that the experimental Mg–Ga–Zn–Ca alloys are characterized by a reduced corrosion rate (5.9–8.2 mm/year) compared to the reference magnesium alloy MA2, and exhibit stable pH evolution of the surrounding medium without abrupt fluctuations. Microstructural analysis revealed the formation of elongated and globular grains with characteristic sizes in the range of 10–30 µm. Bioactivity studies of coatings containing silver nanoparticles, performed using the disk diffusion method, indicated that the onset of antimicrobial activity is characteristic of silver nanoparticles with an average size of approximately 25 nm. Product Description popup.authors Serhii H. Voinarovych Serhii M. Kaliuzhnyi Khokhlov Maksym A. Stelmakh Yaroslav A. Khokhlova Yuliia A. Dyman Marianna M. Maksymchuk Ihor M Fomina Nadiia S. Fomin Oleksandr O. popup.nrat_date 2025-12-24 Close