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Information × Registration Number 0225U005190, (0124U003749) , R & D reports Title Functionalised carbon-based nanomaterials obtained by "green methods" from Ukrainian agricultural waste to combat multilevel neurotoxicity induced by xenobiotic/essential transition metals and arsenic. popup.stage_title Синтез вуглецевих нанопористих матеріалів і наночастинок зі шкаралупи волоського горіха, лушпиння соняшника, різних відходів целюлози, їх характеристика, аналіз здатності до адсорбції важких металів та визначення їх потенційної нейротоксичності, мембраноактивних властивостей, здатності знижувати нейротоксичність, спричинену ксенобіотичними металами Pb, Hg, Cd, біологічно важливими перехідними металами Cu, Fe та металоїдом As у нервових закінченнях мозку. Head Krysanova Nataliya V., Кандидат біологічних наук Registration Date 26-12-2025 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 To synthesize/characterize/functionalize carbon-based nanoporous materials and nanoparticles from Ukrainian agricultural waste using green synthesis principles; to determine neurotoxicity risks of the nanomaterials and capacity to mitigate multilevel neurotoxicity induced by pollutant mixture of xenobiotic/essential transition heavy metals and arsenic (simultaneously preserving Ca-signalling) using own approach in brain nerve terminals; to confirm data using in vivo animal model. popup.description2 Interim report, pages - 19; figures - 4; tables - 1; literature sources - 7. Keywords: green synthesis, functionalized carbon-based nanomaterials, agricultural waste, xenobiotic heavy metals, metalloid, biologically important metals, neurotoxicity, neuroprotection. Object of study: neurotransmitter transport process. Subject of study: rat brain nerve terminals. Research methods: fluorescent, biochemical methods and radioisotope analysis using Shimadzu UV-1900i spectrophotometer and Shimadzu RF-6000 spectrofluorimeter (Shimadzu, Japan), Hidex 600SL scintillation counter (Hidex, Finland). Nanoporous biochar (NPBC) was synthesized from walnut shells, sunflower peels, and various cellulose wastes by pyrolysis. The elemental composition of the obtained carbon material was investigated using energy-dispersive X-ray spectroscopy. Neurochemical studies have shown for the first time that NPBC from walnut shells and sunflower peels do not cause changes in the extracellular level of L-[3H]glutamate and [3H]GABA, do not change the mitochondrial potential, but increase the spontaneous generation of ROS in nerve terminals, i.e., they do not have neurotoxic properties and therefore they are biocompatible and can be used in biotechnology, ecology, and medicine. It has been shown for the first time that carbon materials synthesized from walnut shells and sunflower husks have the ability to chelate heavy metals Hg, Pb, Cd and physiological metals Cu and Fe. The results obtained have significant scientific value, since for the first time an approach to obtaining NPBC using "green" synthesis methods based on agricultural waste has been developed. The proposed methods ensure environmental safety, low cost and reproducibility of the process of obtaining materials without the use of toxic reagents or organic solvents. Product Description popup.authors Pozdniakova Nataliia H. Tarasenko Alla S Borysov Arsenii A. Ivanytsia Mykyta O. Terebilenko Anastasiia V. popup.nrat_date 2025-12-26 Close