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Information × Registration Number 0225U005195, (0125U000710) , R & D reports Title Screening of molecular markers of post-traumatic stress disorder (PTSD) development in combat veterans for elaboration of innovative diagnostic approaches. popup.stage_title Збір біоматеріалу (сироватка та плазма крові) хворих на ПТСР та кількісний аналіз стресіндукованих гормонів і цитокінів. Визначення основних показників функціонування системи гемостазу та аналіз циркуляторного рівня нейроспецифічних протеїнів як маркерів нейродегенерації у пацієнтів з ПТСР. Head Hula Nadiia M., д.б.н. Registration Date 26-12-2025 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 Identification of clinically significant biomarkers for the diagnosis and assessment of the severity of post-traumatic stress disorder (PTSD) acquired as a result of combat actions. popup.description2 The content of stress-induced hormones, cytokines, and coagulation system parameters, as well as the levels of neuro-specific proteins, were determined in the plasma of combatants with post-traumatic stress disorder (PTSD) of varying severity and conditionally healthy donors (control group). Elevated concentrations of stress hormones (cortisol and adrenaline) were observed in mild and moderate PTSD, whereas in severe cases their levels decreased, indicating exhaustion of the body’s adaptive mechanisms. Norepinephrine was consistently reduced in all PTSD groups compared to controls, while dopamine decreased only in moderate PTSD. Increased levels of pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) were found in moderate PTSD, whereas in severe cases their changes were multidirectional, pointing to impaired neuroimmune regulation. In the hemostatic system, elevated fibrinogen, reduced protein C, and accumulation of D-dimer were detected, forming a basis for increased thrombotic risk. Alterations in circulating levels of neuro-specific markers (neurofilament proteins, tau protein, BDNF, GFAP, S100b, and Iba-1) in PTSD patients indicate the development of neurodegenerative processes associated with neuroinflammation, impaired neuroplasticity, and pathological overactivation of neuroglia. This creates conditions for uncontrolled leakage of neuro-specific proteins into systemic circulation, amplifies systemic inflammation, and adds risks of neurodegenerative progression. Implementation of these findings will strengthen national defense capability through the development of effective strategies for early diagnosis, prevention, and treatment of PTSD in military personnel. In the military context, these results open perspectives for the integrated use of molecular indicators as criteria for patient stratification and for creating biomarker-oriented personalized therapies, ensuring preservation of combat readiness and psychophysical health of service members. Product Description popup.authors Volodymyr O. Chernyshenko Tetiana M. Horidko Oleksandr D. Zhukov Tykhomyrov Artem O. Kosiakova Halyna V. Vasyl L. Bilous popup.nrat_date 2025-12-26 Close