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0225U005266,
(0125U002869)
,
Features of the formation of silver nanoparticles by "green" synthesis using chicory extracts
Отримання біологічно активних екстрактів біотехнологічних коренів цикорію та їх характеристика
Bohdanovych Taisa A., Доктор філософії
29-12-2025
Institute of Cell Biology and Genetic Engineering of the National Academy of Sciences of Ukraine
The project is aimed at solving the current scientific problem of finding new bioactive drugs based on plant raw materials, namely the product of modern nanotechnology - silver nanoparticles obtained by "green" synthesis using chicory extracts. Accordingly, the aim of the work is to determine the features of the formation and optimization of the process of obtaining silver nanoparticles via "green" synthesis, using biologically active extracts of biotechnological roots of Cichorium intybus L. The development and optimization of such a method will allow using natural components of extracts (primarily polyphenolic compounds, flavonoids), known for their bioactivity (antioxidant, antiradical, antimicrobial, anti-inflammatory), synthesized in "hairy" roots (with improved biosynthetic activity compared to control roots) to obtain nanoparticles quickly (synthesis begins in a matter of minutes and in 1 hour a colloidal silver solution with a high content of nanoparticles can be obtained), cheap (for synthesis only plant extracts and a silver salt solution are required), accessible (synthesis occurs at optimal temperatures, at atmospheric pressure and without the use of high voltages) and environmentally safe (when using plant extracts, the need to add toxic stabilizers is eliminated, because the components of the extracts themselves have stabilizing properties in relation to the resulting colloidal solution) method. Such colloidal solutions of silver nanoparticles are of considerable interest, as they are known for their antimicrobial activity, which is valuable in the search for new generation drugs to overcome such a significant problem of humanity as antibiotic resistance. Optimization of obtaining such a product is relevant especially in conditions of military operations, for wound treatment and prevention of infection. This product can be used as a potential material for further development of pharmaceuticals with antimicrobial activity.
During the first stage of the work, a preliminary screening of nine lines of biotechnological chicory roots was carried out for the reducing power of their extracts evaluation. Comparison of these lines among themselves and with control roots showed that in all the studied lines of biotechnological roots the reducing activity was higher than in the control. Among these samples, two lines of biotechnological roots were the most promising for further research. Subsequently, the biomass of the roots of these two lines with high reducing capacity was accumulated, ethanol extracts were obtained and characterized for the total content of flavonoids and bioactivity (antioxidant activity). The results showed that the high reducing power correlated with high antioxidant activity and high content of flavonoids. Based on the studies conducted, these samples were selected for the "green" synthesis of nanoparticles in the second stage of the work.
Bohdanovych Taisa A.
2025-12-29
Updated: 2025-12-29
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