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0226U000224,
(0123U100161)
,
Improving chemoradiation therapy for squamous cell carcinoma of the head and neck in extreme conditions.
Розробити схеми індивідуалізації променевого лікування плоскоклітинного раку голови та шиї в екстремальних умовах.
Mitriaieva Nataliia А., Доктор біологічних наук
Starenkyi Viktor P., Доктор медичних наук
06-01-2026
State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine"
To develop the technology of a shortened course of chemoradiation treatment of head and neck cancer in extreme conditions, taking into account the mechanisms of tumor radioresistance.
Object of study: squamous cell carcinoma of the head and neck (SCCHN). Purpose of study: to develop a technology for a shortened course of chemoradiotherapy for head and neck cancer in extreme conditions, taking into account the mechanisms of tumor radioresistance. Research methods and equipment: radiological, morphological, clinical and instrumental, immunoenzymatic, statistical; Clinac 600C linear accelerator, LabAnalyt M201 microplate reader. Theoretical and practical results: It has been established that an accelerated course of remote radiation therapy (RT) in combination with cisplatin and celecoxib in patients with SCCHN increases the complete response rate by 18 % and provides a two-year recurrence-free survival rate of up to 92 %. It was determined that changes in NF-κB, VEGF, and PGE-2 levels coincide with an objective response to RT. With tumor regression, a decrease in the levels of the studied factors is observed, which is most pronounced with RT with cisplatin in combination with celecoxib; the level of NF-κB decreases by 1.8 times, VEGF by 2.3 times, and PGE-2 by 2.8 times against the background of an increase in the number of regressions to 90 %, which indicates the effectiveness of this treatment regimen. With the progression of the tumor process, no decrease in NF-κB, VEGF, and PGE-2 was observed, which is associated with tumor resistance to the therapy. Novelty: for the first time, a technology for accelerated RT course with the use of combined radiomodification taking into account the molecular marker of radio resistance (transcription factor NF-κB) in patients with SCCHN was developed and substantiated, which ensured an increase of the fractional dose to the primary lesion areas up to 2.4 Gy. A set of measures has been developed for the safe treatment of patients with SCCHN in extreme conditions. Effectiveness of implementation: reduction of 14 bed-days. Field of application: oncology, radiation therapy.
Kateryna V. Nemaltsova
Serhii V. Artiukh
Larysa I. Simonova-Pushkar
Nataliia V. Bilozor
Olha V. Slobodianiuk
Olena M. Sukhina
Alla M. Nasonova
Svitlana V. Danyliuk
Lidiya V. Grebinyk
Olena I. Kondrashova
Liudmyla A. Pshyshevska
Ihor O. Samofalov
Viktoriia V. Kolomatska
Serhii V. Izotov
Anastasiia A. Pasmor
Ihor S. Tykholіz
Iryna V. Bilchenko
Hanna V. Hrytsiuta
2026-01-06
Updated: 2026-01-10
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