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Information × Registration Number 0226U000306, (0125U000654) , R & D reports Title Development of combined artificial implants for the restoration of damaged bones for military and civilian surgery. Chapter 1. Development of innovative approaches to the creation of the latest phosphate ceramics and assessment of their biocompatibility popup.stage_title Синтез біоактивних композитів ГАП-ТКФ з різним співвідношенням основних компонентів, що містять іони біоактивних металів (цинк, срібло, натрій) Head Zatovskyi Ihor V., д.х.н. Registration Date 07-01-2026 Organization F. D. Ovcharenko Institute of Biocolloidal Chemistry NAS of Ukraine popup.description1 development of new materials based on nanostructured hydroxyapatite and tricalcium phosphate as the basis of resorbable materials for the treatment of bone tissue defects; providing these composites with antibacterial properties by doping them with silver and zinc ions or combining them with metal nanoparticles (silver); establishing the influence of the phase composition, particle size, nature and concentration of surface functional groups in such systems on the efficiency of their resorption (biotransformation) in the body; development of a technological scheme for creating various forms of implants (powders, porous granules and blocks) and manufacturing their samples for preclinical and clinical testing with the aim of further implementation in medical practice. popup.description2 Methods for obtaining hydroxyapatites (HAP) and structural analogues of tricalcium phosphates (TCP) doped with silver, zinc, and a combination of sodium + silver have been developed. A number of regularities in the formation of HAP + TCF compositions with different component contents depending on the initial Ca/P ratios and the pH value of the solutions have been established. The fundamental possibilities of wide regulation of the component ratios in the indicated nanocompositions (TCF content up to 70 wt.%) during their synthesis in one stage have been shown. The chemical and phase composition of the obtained samples was characterized using analytical and physicochemical research methods (X-ray fluorescence analysis, spectrophotometry, powder radiography and X-ray phase analysis, FTIR spectroscopy, etc.). Based on the obtained results, conclusions were drawn regarding the different mechanisms of doping of GAP and TCF matrices with silver and zinc ions, which determines the different degree of doping of these matrices with the indicated metals. The biocompatibility and safety of a number of obtained samples doped with silver or combinations of sodium + silver were investigated, and their antimicrobial activity against a wide range of pathogens was also tested. Based on the tests, the safety of most synthesized samples was clarified and their antimicrobial activity was established depending on the silver content in the samples. In particular, it was shown that for the series of the general composition AgxNa1-xCa10(PO4)7 with a silver content x ≥ 0.5, a clear antimicrobial effect is manifested, which significantly increases as the amount of silver in the sample increases. Accordingly, the compounds of the above compositions can be used in the manufacture of synthetic implants for bone regeneration with antimicrobial activity. Product Description popup.authors Voitenko Olena Yu. Liudmyla S. Rieznichenko Tsyhanovych Olena A. Vitalii А. Prokopenko Andrii V. Panko Hruzina Tamara H. Volodymyr V. Doroshchuk Viktoriia Oliinyk Dybkova Svitlana M. Lehenchuk Oleksii V. popup.nrat_date 2026-01-07 Close