Search academic texts

Information × Registration Number 0226U000440, (0124U000704) , R & D reports Title To develop approaches to the diagnosis of tuberculosis infection and treatment of multidrug-resistant tuberculosis in children in the context of the war in Ukraine and the postwar period popup.stage_title Визначити особливості клінічного перебігу, лабораторних та радіологічних методів досліджень у дітей, хворих на туберкульоз Head Dotsenko Yaroslava I., Кандидат медичних наук Registration Date 09-01-2026 Organization State organization "National scientific center of phthisiatry, pulmonology and allergology named after F. G. Yanovskyi National academy of medical sciences of Ukraine" popup.description1 To develop an algorithm for managing a case of multidrug-resistant tuberculosis in a child, depending on the age and nature of resistance to anti-TB drugs popup.description2 Object of study – 35 children with multidrug-resistant tuberculosis (TB) and drug-sensitive (DS) TB, archival data from examinations of 405 children. The aim of the study is to develop an algorithm for the management of multidrug-resistant TB in children, depending on the age and nature of resistance to anti-TB drugs. Research methods: clinical and radiological, laboratory, statistical. It has been established that during the war in Ukraine, children are more likely to suffer from pulmonary TB: infiltrative TB (41.1%) and primary TB complex (19.6%). The incidence of extrapulmonary (EP) forms of TB increased: intrathoracic lymph nodes (6.7%), bones and joints (7.8%). The structure of clinical forms of TB has worsened due to an increase in widespread forms (4.6%), destruction (13.0%). In 80.8% of cases, the diagnosis of TB in children is confirmed by computed tomography, in 11.7% – X-ray. 58.6% of those examined have no pathological changes in their complete blood count. 69.3% of children have DS-TB, 30.7% have DR-TB, among which MDR-TB (42.0%), XDR-TB (22.2%), and Rif-TB (22.2%) prevail. The highest percentage of resistance was observed to rifampicin (80.2%) and isoniazid (71.6%). Resistance to delamanid (9.4%), bedaquiline, linezolid, and clofazimine was determined for the first time – 6.3% each, respectively. A negative quantiferon test result is more common in children under 5 years of age (31.8%). In children with DS and MDR-TB, approximately the same percentage of positive results was found – 71.4% and 78.6% of quantiferon test results. A technology has been developed to predict the risk of developing DR-TB in children by determining the most significant predictors, their diagnostic informativeness, and diagnostic coefficients, which allows for a 21.1% increase in the accuracy of prediction and the identification of groups requiring preventive treatment to prevent the development of DR-TB. Scope of application – tuberculosis, paediatrics, pediatric phthisiology. Product Description popup.authors Oksana Y. Sivachenko Iryna Y. Shekhter Viktoriia A. Shatunova Петішкіна Валерія Миколаївна Фірсова Алла Сергіївна Yaroslava I. Dotsenko popup.nrat_date 2026-01-09 Close