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Information × Registration Number 0226U000524, (0124U003838) , R & D reports Title Flow chemistry as an advanced approach for scale up of hazardous processes popup.stage_title Демонстрація переваг та визначення недоліків такого підходу порівняно з класичними методами з використанням реакторів постійного об’єму. Head Volochnyuk Dmytro M., Доктор хімічних наук Registration Date 12-01-2026 Organization Institute of Organic Chemistry NAS of Ukraine popup.description1 The main goal of the project is to create a scientific and technological basis for the development of flow reactors for the safe use of aggressive unstable reagents in large-scale organic synthesis. The use of organometallic compounds will be representative case. The demonstration pros and cons of the proposed approach compared to batch reactors is another valuable goal of the project as well as applying of the developed technology to other dangerous processes and reagents. popup.description2 The assembly and qualification of the UOSlab® Flow Reactor LI3 flow module with three sequential zones (LDA generation → lithiation → electrophilic conversion) for working with organolithium compounds has been completed. Based on a systematic study of more than 100 combinations of substrates and electrophiles, the areas of application and limitations of targeted ortho-metallation and halogen-lithium exchange strategies have been determined. Preparative syntheses of heteroarylcarboxylic acids, boronic esters, and hydroxylated derivatives (yields of 57–96%) were carried out on a kilogram scale with a productivity of up to 1 kg/h. Critical “forbidden zones” associated with precipitation, thermal instability, and side reactions have been identified. A specialized Zincrius-8 zinc flow reactor for generating RZnX from metal zinc cartridges, integrated with the HTE platform, has been created and put into operation. A 116-point HTE screening of Negishi reactions was performed, practical rules for selecting ArX–RZnX–catalyst–solvent combinations were formulated, and viable and unsuitable substrate classes were identified. The kinetic profiles of degradation of organozinc reagents in THF and DMF were determined, three stability classes were established, and storage and transportation protocols and standardized titration methods were developed. A comparison of continuous and batch modes was performed for a series of model transformations (Negishi coupling, homologation of α-amino acids, catalytic carbonylation), which showed better temperature control, an increase in operating temperatures by 20–40 °C, and a reduction in reaction times in continuous mode. The results of the work with diazomethane have been published in peer-reviewed journals. Product Description popup.authors Oleksandr V. Borysov Viacheslav V. Pendiukh Dmytriv Yurii V. Yakovleva Hanna V. Demchuk Oleksandr P. Druzhenko Tetiana V. popup.nrat_date 2026-01-12 Close