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Information × Registration Number 0226U000762, (0125U002002) , R & D reports Title Semiconductor quantum dot–protein bionanocomplexes for biomedical applications: synthesis, research, characterization using machine learning popup.stage_title Синтез та спектроскопічні дослідження біонанокомплексів напівпровідникова КТ – протеїн Head Stoliarchuk Ihor D., Доктор фізико-математичних наук Registration Date 15-01-2026 Organization Drohobych Ivan Franko State Pedagogical University popup.description1 Establishing, based on the obtained array of experimental data and deep machine learning, the mechanisms of interaction of AIIBVI QDs with proteins under different technological synthesis conditions and different structures of quantum dots to obtain stable biocompatible nanoconjugates suitable for medical applications in extreme conditions popup.description2 The use of quantum dots (QDs) containing cadmium has a significant drawback associated with its toxicity. The results of the studies demonstrate a sharp decrease in their toxicity in the case of interaction with proteins, in particular human serum albumin (HSA). This work presents a comprehensive study of the interaction of colloidal quantum dots of AIIBVI type compounds (ZnO, CdTe, CdS), as well as quantum dots of semiconductors AIIBVI containing impurities of 3d-elements of transition metals (Mn, Co), with protein molecules. The spectral characteristics of fluorescence quenching during the interaction of quantum dots with proteins with the formation of the corresponding bionanocomplexes were experimentally investigated. A model of a semiconductor quantum dot interacting with dipolar protein molecules was developed. The developed theory assumes the interaction of dipolar protein molecules with colloidal quantum dots through their polarization and self-consistent electron-deformation coupling. It is shown that electron-deformation interaction plays a major role in the formation and stabilization of the CdTe–protein bionanocomplex in the range of quantum dot diameters of 2–5 nm. Within the framework of the developed model, the dependence of the interaction energy of CdTe quantum dots and human serum albumin on the quantum dot radius was investigated for different values of the electron concentration in the quantum dot and the fraction of its surface coverage by albumin molecules. Theoretical calculations are in good agreement with the results of the analysis of experimental data on the photoluminescence intensity decay of the biocomplex “CdTe quantum dot – human serum albumin”. Using the Drosophila melanogaster model, it is shown that the “CdTe quantum dot – human serum albumin” bionanocomplex exhibits minimal toxicity in contrast to unmodified CdTe QDs, which opens up prospects for its safe use in biological and biomedical applications, in particular in diagnostics Product Description popup.authors Leshko Roman Ya. Dankiv Olesia O. Holskyi Vitalii B. Ugryn Yurii O. Liudmyla I. Pankiv Khrystyna Voitovych Olha V. Leshko Volodymyr R. Karpii popup.nrat_date 2026-01-15 Close