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Registration Number

0226U000792, (0123U101202) , R & D reports

Title

Biomedical aspects of the efficacy and safety of non-steroidal anti-inflammatory drugs in the model of comorbid ossicles

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Протипухлинна, протизапальна, кардіо- та гастроінтестинальна дія різних за селективністю до циклооксигенази нестероїдних протизапальних препаратів за тривалого самостійного та комбінованого застосування з протипухлинними засобами на тлі коморбідних станів

Head

Seredynska Nataliia М., д.мед.н.

Registration Date

15-01-2026

Organization

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

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Study of the effectiveness, safety and some mechanisms of action of non-steroidal anti-inflammatory drugs of different groups for use in models of comorbid conditions

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The feasibility, efficacy, cardio- and gastrointestinal safety and some mechanisms of action of nonsteroidal anti-inflammatory drugs, differing in selectivity for cyclooxygenase, were studied in models of comorbid conditions accompanied by systemic inflammation. The antitumor activity of nonsteroidal anti-inflammatory drugs was established for the first time, the features of their use and mechanisms of their action against the background of an oncoprocess comorbid with rheumatoid arthritis or arterial hypertension were determined. This knowledge proves the need to monitor the state of the cardiovascular and digestive systems, allows optimizing pharmacological correction schemes and improving medical technology for the treatment of comorbid conditions caused by inflammation.

Product Description

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Olena M. Marchenko
Nataliya M. Seredynskaya
Olga O. Khavych
Pus'kov Oleksij Mykolajovych
Tetiana A. Bershova
Oleksandra S. Suvorova
Vasyl S. Khomenko
Tetiana A. Karatsuba
Maksym A. Munko
Larysa P. Babenko
Kateryna S. Marchenko-Tolsta
Oleksandr M. Velychko

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2026-01-15