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Information × Registration Number 0226U000810, (0123U103076) , R & D reports Title Rationale for the new approaches to treatment of combined radiation skin injury which is occur under military condition popup.stage_title Обґрунтування підходів до комплексного лікування комбінованого радіаційного ураження шкіри із застосуванням мезенхімальних стромальних клітин кісткового мозку і фармакологічних засобів на удосконалених синтетичних основах. Head Uzlenkova Nataliia Ye., Кандидат біологічних наук Registration Date 16-01-2026 Organization State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine" popup.description1 Develop approaches to complex treatment of the combined radiation skin damage which is occur under military condition with bone marrow mesenchymal stromal cells and pharmacological agents on improved synthetic ones basics. popup.description2 Object of research: combined radiation and wound skin injuries. Purpose: to develop approaches for the complex treatment of combined radiation skin injuries occurring in military conditions, using bone marrow mesenchymal stromal cells and pharmacological agents on improved synthetic bases. Methods: radiobiological, hematological, cell cultivation, and statistical. Equipment: CLINAC 6 MeV linear accelerator, Faxitron MultiRad 225 X-ray unit, UNIDOS universal dosimeter, MN 120 laminar flow cabinet, EC-160 CO2 incubator, NF 800 centrifuge, Leica 6000B microscope, Leica DFC 310 FX digital camera, Leica DM IL LED microscope, Axiolab 94D 2601 microscope, analytical balance. Theoretical and practical results: in the model of combined radiation and skin wound injuries under the total irradiation at a doses of 5.5 Gy and 6.2 Gy, it was established that mortality increased by 20–25%, the time to death reduced by 7–9 days, and the profile of radiation death shifted to the first 5 days. It was determined that both total irradiation and local radiation irradiation at a dose of 50 Gy delayed healing and extended the period of complete wound closure by 10–12 days, depending on the initial wound size. Novelty: it was established for the first time that in combined radiation and wound damage, therapeutic administration of cultured/cryopreserved bone marrow mesenchymal stromal cells reduced systemic inflammation by the level of C-reactive protein and recovery of hematological parameters, increased survival by 20%, and reduced skin wound healing time by 12–14 days. Local application of a combined hyperosmolar-based agent with antimicrobial and dehydrating activity reduced edema and the infectious load in the open wound, preventing local wound complications at the initial stage after combined radiation injury. The field of use: radiobiology. Product Description popup.authors Olena P. Bezuhla Mykola O. Lyapunov Nataliya G. Skorobogatova Svitlana V. Danyliuk Yuliana V. Pavlichenko Iryna O. Leonova Olena L. Maslennikova Olena V. Neniukova Tetiana M. Mamatkulova Lyudmila P. Shelkovaya Zulfiia A. Mamatkulova Olena O. Novikova popup.nrat_date 2026-01-16 Close