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Information × Registration Number 0226U001292, (0125U000679) , R & D reports Title To develop stratification criteria for the use of neoadjuvant androgen deprivation therapy before radical prostatectomy in patients with prostate cancer popup.stage_title Визначити вплив неоад’ювантної андроген-деприваційної терапії на ранні та віддалені онкологічні результати залежно від схеми та тривалості Head Hryhorenko Viacheslav M., Доктор медичних наукShuliak Oleksandr V., д.мед.н. Registration Date 23-01-2026 Organization State Institution "Academician O.F. Vozianov Institute of Urology of the National Academy of Medical Sciences of Ukraine" popup.description1 To improve the results of surgical treatment of patients with prostate cancer under martial law by evaluating the effect of neoadjuvant androgen deprivation therapy before radical prostatectomy on clinical and laboratory parameters, pathological and molecular genetic tissue parameters, as well as oncological outcomes, followed by identification of the optimal regimen and development of stratification criteria for effectiveness popup.description2 The object of the study was 175 patients with prostate cancer who underwent radical prostatectomy with or without prior neoadjuvant androgen deprivation therapy. The aim of the study was to determine the effect of neoadjuvant androgen deprivation therapy on the perioperative course, pathological changes, as well as early and long-term oncological outcomes of radical prostatectomy, depending on the regimen and duration of its use. Research methods included clinical, laboratory, radiological, morphological, statistical, and analytical methods. A retrospective analysis was performed on 175 patients who underwent radical prostatectomy, of whom 84 received neoadjuvant androgen deprivation therapy, and 91 constituted the comparison group. They were stratified according to the duration of therapy (1-2 months, 3 months, more than 3 months) and its intensity (androgen deprivation therapy only and maximum androgen blockade). The data obtained were processed on a personal computer using IBM SPSS Statistics 22 and GraphPad Prism 10.4.1 software packages. The following statistical methods were used: Mann-Whitney and Kruskal-Wallis tests, χ² test, logistic regression, Kaplan-Meier curves, and Cox proportional hazards model. It was found that neoadjuvant androgen deprivation therapy does not worsen the course of the perioperative period. A tendency toward a decrease in the volume of intraoperative blood loss and a reduction in the duration of surgical intervention was revealed. In the group that received therapy for more than 3 months, a decrease in the volume of the prostate gland (33.4±7.2 cm³ vs. 42.1±8.5 cm³; p<0.001) and an increase in the frequency of pathological stage reduction (28.6% vs. 13.2%; p=0.018) were noted. The frequency of positive surgical margins was lower (21.4% vs. 34.1%; p=0.045), as was perineural invasion (36.9% vs. 52.7%; p=0.039). Product Description popup.authors Valerii S. Sakalo Viacheslav M. Hryhorenko Rostyslav O. Danylets Oleksandr V. Shuliak Anatolii V. Sakalo Mykola D. Sosnin Yevhenii I. Afanas'iev Ihor K. Kholokharenko Liudmyla H. Vonifatova popup.nrat_date 2026-01-23 Close