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Information × Registration Number 0226U001350, (0123U100750) , R & D reports Title Development of morphological criteria for the effectiveness of prophylactic and therapeutic effects of malopolar minor lipids in insulin resistance and type 2 diabetes popup.stage_title Розроблення морфологічних критеріїв ефективності профілактичного і терапевтичного впливу малополярних мінорних ліпідів за інсулінорезистентності та цукрового діабету 2 типу Head Kvitnytska-Ryzhova Tetiana Yu., д.б.н. Registration Date 24-01-2026 Organization D. F. Chebotarev Institute of Gerontology of the National academy of the medical sciences of Ukraine popup.description1 To study in an experiment on rats the age-related features of the morphogenesis of IR and T2T and to develop morpho-functional criteria for evaluating the effectiveness of the preventive and therapeutic action of new pharmacological agents, in particular, substances of the class of low-polar minor lipids for the introduction into practice of preclinical studies and screening of substances with high biological activity. popup.description2 After modeling insulin resistance and type 2 diabetes by keeping rats on a high-fat diet (6 months), destructive-dystrophic and inflammatory processes, mitochondrial dysfunction and cell death (apoptotic or necrotic) were detected in the studied target organs (pancreas, liver, heart, brain) of old animals, which were more profound, often irreversible, in nature than in young ones. Morpho-functional criteria for assessing the effectiveness of the preventive and therapeutic action of a new pharmacological corrective agent N-steroylethanolamine (NSE), which belongs to the class of low-polar minor lipids, were developed. A unified histological study protocol was developed, created to objectify and standardize the assessment of morphological changes in the organ. The criteria for assessing morphological changes were built according to the following categories: qualitative – changes are absent ("+") or present ("-"); quantitative – calculation of relevant parameters using morphometry; semi-quantitative. This can be used both for objective characterization of the course and prognosis of the pathological process, and for the development of new therapeutic agents and assessment of their effectiveness. Product Description popup.authors Luhovskyi Serhii P. Mykhalskyi Serhii A. Klymenko Pavlo P. Malysheva Svitlana P Lydmila I. Kolomiets Olha A. Pryiatel Valentyna V. Havrylei popup.nrat_date 2026-01-24 Close