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Information × Registration Number 0226U001365, (0122U200159) , R & D reports Title Profiles and functional role of metabolites of bacteria of the genera Bacillus and Pseudomonas popup.stage_title Експериментальне підтвердження визначених молекулярним докінгом потенційних мішеней антибіотика батуміну. Дослідження мутагенної і цитотоксичної дії антибіотика батуміну. Head Avdieieva Liliia V., Доктор медичних наук Registration Date 24-01-2026 Organization Institute of Microbiology and Virology. D.K. Zabolotny National Academy of Sciences of Ukraine popup.description1 Based on the obtained metabolic profiles of bacteria of the genera Bacillus and Pseudomonas to determine the functional role of their metabolites popup.description2 It has been established that the antibiotic batumin has different targets of action than the well-known antibiotic mupirocin, which is active against staphylococci. Therefore, batumin may be an alternative to the latter. Batumin also has the highest cytotoxic activity against UCT-Mel 1 (melanoma) cancer cells and does not cause cell mutations. For the first time, a composition of three pyocins was created and proven to be effective in inhibiting the growth of multidrug-resistant strains of Pseudomonas aeruginosa, as well as strains of this genus isolated from plants. Such a composition of pyocins is promising in the composition of drugs for the treatment of superficial infections, the etiological factor of which are multidrug-resistant strains of P. aeruginosa. It has been proven that feeding fish with feed containing the probiotic strain B. velezensis IMV B-7571 has a positive effect on the antioxidant status of carp fry, helps reduce damage to cell membranes, and positively affects the histological parameters of the kidneys, liver, and gastric glands, which indicates the promise of this strain as a component of biological preparations for fish farming. Product Description popup.authors Liudmyla V. Yaroshenko Oleksii O. Nechypurenko Kharkhota Maksim A. Klochko Vitalij Viktorovych Balko Oleksandr B. Korzh Julia Volodimirovna Maksym S. Kharchuk Rybalchenko Nataliia P. Valentyna O. Kozyreva Zvitana Korol Liudmyla M. Poberezhna Olha I. Balko Larysa L. Mozhaieva Olha A. Okhota Alina V. Kharchuk popup.nrat_date 2026-01-24 Close