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Information × Registration Number 0226U001447, (0123U100771) , R & D reports Title To investigate cognitive and neuropsychological disorders in internally displaced patients with Parkinson's disease in order to optimize their complex pathogenetic therapy popup.stage_title Дослідити когнітивні та нейропсихологічні порушення у внутрішньо переміщених пацієнтів із хворобою Паркінсона для оптимізації їх комплексної патогенетичної терапії Head Karaban Iryna M., Доктор медичних наук Registration Date 27-01-2026 Organization D. F. Chebotarev Institute of Gerontology of the National academy of the medical sciences of Ukraine popup.description1 Develop a comprehensive diagnosis of cognitive and neuropsychological disorders in the early and severe stages of Parkinson's disease on the basis of basic assessments of their relationship with the level of prooxidant-antioxidant balance to improve and implement effective pathogenetic therapy. popup.description2 It has been established that the result of prolonged stress caused by the war is the development of various psychoemotional disorders, in particular, anxiety and depressive states, post-traumatic stress disorder. Compared with the control group of elderly people who were permanently resident in the Kyiv region during the war, internally displaced patients with PD had statistically significantly higher levels of situational anxiety and depression, and a significantly higher risk of developing PTSD. For the first time, a study of the morpho-functional characteristics and assessment of mitochondrial dysfunction at different stages of the clinical course of Parkinson's disease in patients with cognitive disorders was conducted. For the first time, the prognostic significance of oxidative stress markers for predicting and assessing the effectiveness of complex treatment of PD was shown, and potential markers of mitophagy induction, which leads to an increase in oxidative stress, were identified. The obtained results of research on the structural-functional and neurophysiological features of the integrative activity of the brain in CP allow for a comprehensive assessment of the severity of PTSD associated with war and the prospects for optimizing pathogenetic therapy of the disease in this category of patients. Considering the identified complex dependencies between markers of oxidative stress and the effectiveness of CP therapy, the study of these markers will improve the assessment of treatment effectiveness and allow for a more effective implementation of a personalized approach. The effectiveness of the use of the neuroprotector EGb 761 in the complex pathogenetic treatment of CP at all stages of the disease has been shown for the first time. Product Description popup.authors Luhovskyi Serhii P. Bondarenko Olena V Kvitnytska-Ryzhova Tetіana Yuriivna Shatylo Valerii B. Rozova Kateryna V. Olexiy O. Barsukov Pysaruk Anatolii V. Naskalova Svetlana S Koshel Natalya M Klymenko Pavlo P. Dmytro S. Krasnenkov Karasevich Nina V Rozhkova Zinaida Z Olha A. Pryiatel Tetiana B. Papurina Kostiantyn K. Midlovets Iryna V. Zaiets popup.nrat_date 2026-01-27 Close