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Information × Registration Number 0226U001837, (0121U109057) , R & D reports Title Investigation of adaptive and metabolic processes in animals under the action of biologically active substances of different origin popup.stage_title Дослідити адаптивні та метаболічні процеси в організмі тварин за дії біологічно активних речовин різного походження Head Ponkalo Lesia Ihorivna, к.вет.н. Registration Date 02-02-2026 Organization Institute of Animal Biology of the National Academy of Agrarian Sciences of Ukraine popup.description1 The aim of research is to determine the effect of biologically active substances of different origins on physiological and biochemical processes in animals during their adaptation to environmental conditions popup.description2 Research in 2021–2025 established biochemical mechanisms of animal adaptation to environmental and climatic challenges and developed methods for increasing their stress resistance. It was found that the use of thiosulfonate supplements (100 mg/kg) for 21 days is safe, and the compounds S-ethyl- and S-allyl-4-aminobenzenethiosulfonate most effectively activate the enzymes SOD and catalase, preventing free radical peroxidation. It was found that the amino acid L-Glu neutralizes the effects of CCl_4-induced stress, bringing the indicators of antioxidant enzymes (GPO, SOD, GSH) closer to normal levels. Particular attention was paid to overcoming heat stress (HS). It was found that HS causes hyperthermia, a decrease in the level of erythrocytes and hemoglobin, as well as a weakening of antioxidant defense. The addition of L-arginine (100 mg/kg) intensifies protein metabolism, increases the weight gain of rabbits by 8% and exhibits a pronounced stress-protective effect. The combined use of L-arginine (50–100 mg/kg) and betaine (300 mg/kg) effectively restrains the increase in rectal temperature, stabilizes the pulse rate and maintains a high level of blood oxygenation under conditions of overheating. In particular, betaine reduces the level of TBA-active products, reducing the intensity of oxidative damage. The increase in nitrate toxicity with increasing temperature was studied: an increase in temperature by 21°C reduces the life span of animals poisoned by sodium nitrite by 40% (toxicity coefficient 0.59), which indicates a critical decrease in the adaptive reserve. Based on the results, to maintain animal productivity and mitigate the impact of TC, prophylactic feeding of a mixture of L-arginine and betaine 7–10 days before the predicted warming is recommended. Product Description popup.authors Iryna Y. Oliynyk Nataliya O. Salyha Nadiia I. Pryimych Bohdan I. Kotyk Sofiia I. Fedoryshyn popup.nrat_date 2026-02-02 Close