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Information × Registration Number 0226U001846, (0125U001633) , R & D reports Title New synthetic substances with antimicrobial properties for treating wounds popup.stage_title Нові синтетичні речовини з антимікробною дією для обробки ран Head Kozak Mariia R., Кандидат біологічних наук Registration Date 02-02-2026 Organization Institute of Animal Biology of the National Academy of Agrarian Sciences of Ukraine popup.description1 To develop and investigate the effectiveness of a new drug with antimicrobial action created on the basis of a synthetic analogue of raw materials of plant origin for the treatment of wounds and wound surfaces popup.description2 Organosulfur compounds, analogues of natural biologically active substances of plant origin, have been synthesized. The advantage of synthetic organosulfur compounds over natural analogues is resistance to degradation and, accordingly, prolongated antimicrobial effect. Liquid forms of the synthesized compounds were developed and their effect on the growth of microorganisms in vitro was studied. Compound ETC1 showed high antibacterial activity against E. coli, S. aureus, and C. albicans. Compound ETC2 also has high antibacterial and antifungal activity, but weaker than ETC1. The minimum inhibitory concentrations of the developed liquid forms of new synthetic substances (ETS1 and ETS2) were determined. The compound with the most effective antimicrobial effect was selected. An experimental preparation based on S-ethyl-4- aminobenzenethiosulfonate in a 50% dimexide solution was formed. New experimental drug provides wound protection and scar-free healing in mice. The scientific novelty of the project is established relationship of chemical structure and antimicrobial activity. This will help scientists to overcome the resistance of microorganisms via creating effective methods of modification and synthesis of known and new antimicrobial substances. Practical value of the proposed work lies in the possibility of developing new, effective, safe and easy-to-use medicines for healing wounds and injuries of various etiologies. Product Description popup.authors Nataliia V. Kuzmina Iryna M. Petrukh Yurii V. Martyn popup.nrat_date 2026-02-02 Close