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Information × Registration Number 0226U002060, (0124U001483) , R & D reports Title Cellular and molecular mechanisms of hypoxia influence in pathological processes associated with combat trauma and its consequences. popup.stage_title Дослідження клітинних та субклітинних механізмів впливу гіпоксії при крововтраті. Head Portnichenko Alla H., д.мед.н. Registration Date 06-02-2026 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 To establish the role of hypoxia in pathological processes associated with combat trauma and its consequences (blood loss, tissue damage and repair, inflammation, neurological and metabolic disorders), at the cellular and molecular level, and to develop correction methods. popup.description2 A method for modeling mixed blood loss from the femoral vessels in rats with tourniquet application has been developed. When reproducing blood loss of 25% of the circulating blood volume, it was found that alterative and reparative processes, as well as survival during blood loss, depend on the level of energy metabolism and can be modulated by hypoxic load, including the application of a limb tourniquet. The application of a tourniquet worsened the circulatory component of hypoxia and immediate lethality, was accompanied by an increase in oxidative stress in organs and tissues and damage to their ultrastructure, and did not contribute to cellular recovery during blood loss. Product Description popup.authors Irina M. Man'kovs'ka Євген В. Моісеєнко Alla H. Portnychenko Olha I. Harmatina Olha O. Honchar Oleksandr M. Bakunovskyi Maryna I. Vasylenko Oksana O. Klymenko Nataliia M. Vashchenko Mariia H. Dubova Mariia H. Kozlovska Kateryna V. Rozova popup.nrat_date 2026-02-06 Close