Search academic texts

Information × Registration Number 0226U002234, (0124U001542) , R & D reports Title Functional features of neurons of the central and autonomic nervous systems in models of systemic pathological conditions. popup.stage_title Роль інсуліна в декомпенсації змін глутаматергічної синаптичної пластичності в сенсорних ноцицептивних синапсах під впливом гіперглікемії та гіпоінсулінемії та визначення впливу короткотривалої гіпоксії на натрієві канали в культивованих гангліозних клітинах сітківки. Head Veselovskyi Mykola S., Доктор біологічних наук Registration Date 12-02-2026 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 Elucidation of the main mechanisms of dysregulation of electrical activity and synaptic dysfunction of neurons of the peripheral and central nervous system in hyperglycemia, hypoinsulinemia, hypoxia and insulin resistance and determination of methods of their correction. popup.description2 In co-culture of spinal ganglion and dorsal horn neurons of the spinal cord, primary culture of dissociated trigeminal ganglion cells and culture of retinal ganglion neurons, the contribution of AMPA receptors to the implementation of glutamatergic neurotransmission in nociceptive sensory synapses, the specificity of the potential-independent modulatory effect of norepinephrine on high-threshold calcium channels in relation to its concentration, and the effect of acute hypoxia on sodium currents we determined. The postsynaptic nature of insulin modulation of the eEPSC in nociceptive sensory synapses and the determining role of endocytosis of postsynaptic GluR2-containing AMPA receptors of the plasma membrane in this process and low levels of the βγ subunit of the G protein in trigeminal ganglion neurons were confirmed. The phenomenons of fast Na+ current inhibition by acute hypoxia and potentiation of this current by hypoxia under of daily preconditioning of retinal ganglion cells with melatonin has been demonstrated for the first time. Product Description popup.authors Yaroslav М. Hotsuliak Mariia S. Shypshyna Hanna V. Dumanska Svitlana A. Fedulova Olena E. Purnyn Mykola S. Veselovskyi Oleh V. Rykhalskyi Vitalii Y. Maslov Serhii V. Voitenko Ihor M. Remizov popup.nrat_date 2026-02-12 Close