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Information × Registration Number 0226U002262, (0121U110055) , R & D reports Title Determination of molecular processes involved in the development of preeclampsia through the integration of transcriptome, proteome and metabolic data in the human placenta popup.stage_title Порівняльний аналіз транскриптому в суцільній тканині плаценти людини за умов фізіологічного перебігу вагітності і прееклампсії Head Obolenska Mariia Yu., д.б.н. Registration Date 12-02-2026 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 Preeclampsia is a life-threatening disease of pregnant women, which occurs with a frequency of 5-10% in the world and is characterized by high blood pressure and the appearance of protein in the urine after the 20th week of pregnancy. In case of untimely termination of pregnancy, preeclampsia turns into eclampsia - convulsions, which often end in the death of mother and child. Placental dysfunction plays a leading role in the occurrence of preeclampsia. The aim of the project is to conduct a systematic analysis of the transcriptome, proteome and metabolite in the human placenta under physiological conditions of pregnancy, preeclampsia and in women smokers, in whom the incidence of preeclampsia is twice lower than in women who do not smoke. Identifying the factors that contribute to and support the disease and that prevent its occurrence is one of the features of this project. To achieve the main goal of the project, two approaches will be used - bioinformatics analysis of publicly available data and experimental studies aimed at validating the results of bioinformatics analysis, search for new markers of the pathological process and factors that contribute to seizures. popup.description2 Objective. The aim of this study was to perform an integrative analysis of gene expression data in the human placenta from the first and second trimesters of normal pregnancy and to compare them with existing data. Results. Gene expression data from six studies of human placental gene expression profiles across the three trimesters of pregnancy were downloaded from the open databases GEO and ArrayExpress using the R package ArrayExpress. Corresponding standardized metadata were retrieved from our in-house developed IGEA database. Categorization of differentially expressed genes by biological processes revealed two major clusters: immune processes and angiogenesis. Conclusion. During the transition from the first to the second trimester of gestation, immune processes are activated in the placenta. These include protective mechanisms against harmful factors along the maternal–fetal interface, provision of the fetus with its own defense mechanisms, and maintenance of immunotolerance, as well as processes associated with the development of the placental vascular system. Product Description popup.authors Frolova Alina O. Chabanova Mariia V. Oleksandr K. Lykhenko popup.nrat_date 2026-02-12 Close