Search academic texts

Information × Registration Number 0226U002443, (0125U002306) , R & D reports Title Development and production of a recombinant activator of the blood coagulation system using plant expression systems, with the goal of scaling up the manufacturing of highly effective hemostatic agents. popup.stage_title Створення та продукція рекомбінантного активатора системи зсідання крові у рослинних системах експресії з метою масштабування виробництва високоефективних кровоспинних засобів. Розділ 2, Етап 2025 року Head Kuchuk Mykola V., Доктор біологічних наук Registration Date 24-02-2026 Organization Institute of Cell Biology and Genetic Engineering of the National Academy of Sciences of Ukraine popup.description1 This approach involves adapting and utilizing plant expression systems to produce a highly specific coagulation activator, enabling the scalable production of hemostatic agents with targeted hemostatic effects. These agents are designed for efficient bleeding control and can be integrated into combined hemostatic and wound-healing formulations for use in surgical settings and field conditions. popup.description2 As a result of the work, genetic vector constructs containing the gene coding the target protein ecarin and adapted for expression in plant cells were created and tested. Genetic constructs were transferred into bacterial cells for multiplication and storage of DNA molecules, as well as for infection and production of the target recombinant protein ecarin in plant cells. We have shown for the first time in the world the possibility of obtaining a biologically active snake venom protein (ecarin), which was able to rapidly clot blood plasma, in plant cells. The advantage of this method is to increase the safety of biological products for humans with an orientation towards the concept of sustainable development. Product Description popup.authors Andrii O. Potrokhov Yana Sindarovska Anastasiia A. Khotieieva popup.nrat_date 2026-02-24 Close