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Information × Registration Number 0226U002456, (0123U102103) , R & D reports Title Rational design of muscarinic acetylcholine receptor type 2 activators as potential components of acute myocardial infarction and myocardial wound therapy popup.stage_title Оптимізація фізико-хімічних параметрів найбільш селективних та активних інгібіторів mAChRs для покращення біодоступності та зменшення токсичності сполук. Head Nyporko Oleksii Yu., Кандидат біологічних наук Registration Date 25-02-2026 Organization Taras Shevchenko National University of Kyiv popup.description1 The strategic aim of the project is to search for and/or develop compounds - high-affinity and selective activators of muscarinic acetylcholine receptors of type 2, which can be effectively used in the emergency treatment of both acute myocardial infarction and wound injuries, which is especially relevant in war and post-war rehabilitation. popup.description2 The strategic goal of the project is to develop low-molecular weight agonists of muscarinic acetylcholine receptors of the second (M2) type, the activation of which restores the balance of the vegetative tone of the heart muscle, reduces the intensity of pain signals, and prevents massive cardiomyocyte death during ischemia-reperfusion, with the subsequent creation of new drugs based on them for the emergency treatment of acute myocardial infarction and myocardial wound injury, which is especially relevant in conditions of war and post-war rehabilitation. During the project, using modern computational approaches, the structural features of the acetylcholine-binding site of the M2-type muscarinic acetylcholine receptors in humans were studied, and new synthetic low-molecular weight compounds capable of activating these receptors were identified. their affinity to target receptors was assessed, after which their pharmacological properties and parameters were studied using a number of physiological and pharmacological methods on a model of smooth muscles and cardiovascular vascular activity in rats, which allowed the identification of new lead compounds for the development of new drugs for the emergency treatment of acute myocardial infarction and myocardial injuries. Product Description popup.authors Voiteshenko Ivan S. Savchenko Oleksandr V. Emelyanov Vladimir Igorevich Olha V. Tsymbaliuk Symonenko Yurii V. Veronika H. Chervetsova Drahan Anatolii I. Ahnesa T. Syniuhina Burianov Volodymyr V. Hrebinchuk Veronika R. Morozova Nadiia M. Musiienko Andrii M. SERHII SUKHOPARA TETIANA FEDIRKO popup.nrat_date 2026-02-25 Close