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Information × Registration Number 0226U002494, (0124U001685) , R & D reports Title Molecular and genetic mechanisms of neurodegeneration in mouse brain involving proinflammatory cytokines in the modeling of posttraumatic stress disorder popup.stage_title Визначення маркерів запалення, вільно-радикальних процесів та порушення метаболізму вуглеводів та ліпідів у мишей з експериментальним посттравматичним стресовим розладом Head Dosenko Viktor Ye., Доктор медичних наук Registration Date 25-02-2026 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 The aim of the study is to establish the pathogenetic significance of non-coding RNAs, hypoxia-inducible factor, senescent cells and neuroinflammation in PTSD and to evaluate the effectiveness of experimental therapy of this disease using intermittent hypoxia-hyperoxia and specific inhibitors of HIF prolyl hydroxylase. popup.description2 At the molecular level, it was shown for the first time that the expression of the long non-coding RNA Hotair is significantly increased in the amygdala and medial prefrontal cortex of mice with experimental PTSD, while the levels of Malat1 and Gas5 remain unchanged. The increase in Hotair expression was accompanied by selective induction of Tnf-α mRNA in the amygdala and a strong positive correlation between the levels of Hotair and Tnf-α in both studied brain structures. The obtained data indicate the activation of a specific Hotair–Tnf-α axis in the pathogenesis of PTSD. In the offspring of the first generation of mice exposed to SPS (single prolonged stress), changes in motor activity, exploratory behavior, fear responses and a hyperactive behavioral profile in the elevated plus maze were detected, which indicates a possible vertical transmission of stress-induced neurobiological changes. Product Description popup.authors Dmytro О. Stroi Denis О. Pashevin Vasyl S. Nagibin Anzhela M. Shysh Ruslan B. Strutynskyi Lesia V. Tumanovska Serhiy V. Goncharov Mykhaylo R. Hetsuriani Denys F. Porkhalo Viktor Y. Dosenko Bohdan Y. Haran Roman R. Vasyl popup.nrat_date 2026-02-25 Close